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Schema
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Pathway
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Entries
Pre-NOTCH Processing in Golgi
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authored
[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
compartment
[Compartment:20699] Golgi membrane
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17963] Golgi lumen
[Compartment:876] plasma membrane
created
[InstanceEdit:1912419] Orlic-Milacic, M, 2011-11-01
dbId
1912420
displayName
Pre-NOTCH Processing in Golgi
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-1912374] Transport of NOTCH precursor to Golgi - Homo sapiens
[Reaction:R-HSA-1912369] NOTCH precursor cleaved to form mature NOTCH - Homo sapiens
[Reaction:R-HSA-1912355] Glycosylation of Pre-NOTCH by FRINGE - Homo sapiens
[Reaction:R-HSA-1912352] Galactosylation of Pre-NOTCH - Homo sapiens
[Reaction:R-HSA-1912378] Sialylation of Pre-NOTCH - Homo sapiens
[Reaction:R-HSA-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Homo sapiens
[BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens
[BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:157105] The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
[LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
[LiteratureReference:157153] A homolog of Drosophila Notch expressed during mammalian development
[LiteratureReference:157055] Notch2: a second mammalian Notch gene
[LiteratureReference:157003] Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
[LiteratureReference:1602209] The developmental role of warthog, the notch modifier encoding Drab6
[LiteratureReference:2032754] SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells
[LiteratureReference:2032749] Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans
[LiteratureReference:2032748] Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality
[LiteratureReference:1602189] Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
[LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch
[LiteratureReference:2023165] A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
[LiteratureReference:1602195] Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
[LiteratureReference:157112] The Notch1 receptor is cleaved constitutively by a furin-like convertase
[LiteratureReference:2033398] Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2
[LiteratureReference:157059] Calcium depletion dissociates and activates heterodimeric notch receptors
[LiteratureReference:157123] Roles for proteolysis and trafficking in notch maturation and signal transduction
[LiteratureReference:157051] Oh no, Notch again!
[LiteratureReference:1911393] p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Pre-NOTCH Processing in Golgi
orthologousEvent
[Pathway:R-MMU-1912420] Pre-NOTCH Processing in Golgi - Mus musculus
[Pathway:R-RNO-1912420] Pre-NOTCH Processing in Golgi - Rattus norvegicus
[Pathway:R-BTA-1912420] Pre-NOTCH Processing in Golgi - Bos taurus
[Pathway:R-SSC-1912420] Pre-NOTCH Processing in Golgi - Sus scrofa
[Pathway:R-XTR-1912420] Pre-NOTCH Processing in Golgi - Xenopus tropicalis
[Pathway:R-GGA-1912420] Pre-NOTCH Processing in Golgi - Gallus gallus
[Pathway:R-DME-1912420] Pre-NOTCH Processing in Golgi - Drosophila melanogaster
[Pathway:R-CEL-1912420] Pre-NOTCH Processing in Golgi - Caenorhabditis elegans
releaseDate
2012-03-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165114] Joutel, A, 2004-12-15
[InstanceEdit:2121207] Haw, R, 2012-02-06
revised
[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1912420
summation
[Summation:2043919] NOTCH undergoes final posttranslational processing in the Go...
Referrals
(hasEvent)
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
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