Reactome | Pre-NOTCH Processing in Golgi

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Pre-NOTCH Processing in Golgi Show undefined attributes

authored	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
compartment	[Compartment:20699] Golgi membrane [Compartment:12045] endoplasmic reticulum membrane [Compartment:17963] Golgi lumen [Compartment:876] plasma membrane
created	[InstanceEdit:1912419] Orlic-Milacic, M, 2011-11-01
dbId	1912420
deleted	[Deleted:9034326] Deletion of instance: 157122
displayName	Pre-NOTCH Processing in Golgi
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
eventOf	[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-1912374] Transport of NOTCH precursor to Golgi - Homo sapiens [Reaction:R-HSA-1912369] NOTCH precursor cleaved to form mature NOTCH - Homo sapiens [Reaction:R-HSA-1912355] Glycosylation of Pre-NOTCH by FRINGE - Homo sapiens [Reaction:R-HSA-1912352] Galactosylation of Pre-NOTCH - Homo sapiens [Reaction:R-HSA-1912378] Sialylation of Pre-NOTCH - Homo sapiens [Reaction:R-HSA-1912372] Fringe-modified Pre-NOTCH is cleaved by FURIN - Homo sapiens [BlackBoxEvent:R-HSA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-1912379] Transport of fringe-modified NOTCH to plasma membrane - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:157105] The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium [LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane [LiteratureReference:157153] A homolog of Drosophila Notch expressed during mammalian development [LiteratureReference:157055] Notch2: a second mammalian Notch gene [LiteratureReference:157003] Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene [LiteratureReference:1602209] The developmental role of warthog, the notch modifier encoding Drab6 [LiteratureReference:2032754] SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells [LiteratureReference:2032749] Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans [LiteratureReference:2032748] Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality [LiteratureReference:1602189] Glycosyltransferase activity of Fringe modulates Notch-Delta interactions [LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch [LiteratureReference:2023165] A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway [LiteratureReference:1602195] Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1 [LiteratureReference:157112] The Notch1 receptor is cleaved constitutively by a furin-like convertase [LiteratureReference:2033398] Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2 [LiteratureReference:157059] Calcium depletion dissociates and activates heterodimeric notch receptors [LiteratureReference:157123] Roles for proteolysis and trafficking in notch maturation and signal transduction [LiteratureReference:157051] Oh no, Notch again! [LiteratureReference:1911393] p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Pre-NOTCH Processing in Golgi
orthologousEvent	[Pathway:R-MMU-1912420] Pre-NOTCH Processing in Golgi - Mus musculus [Pathway:R-RNO-1912420] Pre-NOTCH Processing in Golgi - Rattus norvegicus [Pathway:R-BTA-1912420] Pre-NOTCH Processing in Golgi - Bos taurus [Pathway:R-SSC-1912420] Pre-NOTCH Processing in Golgi - Sus scrofa [Pathway:R-DRE-1912420] Pre-NOTCH Processing in Golgi - Danio rerio [Pathway:R-XTR-1912420] Pre-NOTCH Processing in Golgi - Xenopus tropicalis [Pathway:R-GGA-1912420] Pre-NOTCH Processing in Golgi - Gallus gallus [Pathway:R-DME-1912420] Pre-NOTCH Processing in Golgi - Drosophila melanogaster
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165114] Joutel, A, 2004-12-15 [InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1912420
summation	[Summation:2043919] NOTCH undergoes final posttranslational processing in the Go...
updateTrackers	[UpdateTracker:9775926] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v78:[updateContainedRLE] [UpdateTracker:9783368] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v56:[updateContainedRLE] [UpdateTracker:9788671] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v41:[modifyText, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
(replacementInstances)	[Deleted:9034326] Deletion of instance: 157122
(updatedInstance)	[UpdateTracker:9775926] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v78:[updateContainedRLE] [UpdateTracker:9783368] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v56:[updateContainedRLE] [UpdateTracker:9788671] Update Tracker - [Pathway:1912420] Pre-NOTCH Processing in Golgi - v41:[modifyText, updateContainedRLE]

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