Reactome | Toll Like Receptor 3 (TLR3) Cascade

Toll Like Receptor 3 (TLR3) Cascade

Stable Identifier

R-HSA-168164

Type

Pathway

Species

Homo sapiens

Related Species

Human herpesvirus 1, Hepatitis C Virus, Hepatitis B virus, Rotavirus, Influenza A virus

ReviewStatus

5/5

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Toll-like receptor 3 (TLR3) as was shown for mammals is expressed in various tissues and cells, including myeloid dendritic cells, macrophages, respiratory and intestinal epithelium, neurons and microglial cells to induce antiviral and inflammatory responses of the innate immunity in combating viral infections.

TLR3 recognizes dsRNA in the endosome and that triggers the receptor dimerization. TLR3 recruits the adaptor TRIF (TICAM1), leading to the activation of NF-kappa-B and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways.

Literature References

PubMed ID	Title	Journal	Year
15733829	Transcriptional signaling by double-stranded RNA: role of TLR3 Sarkar, SN, Sen, GC	Cytokine Growth Factor Rev	2005
18202435	Sensing of viral infection and activation of innate immunity by toll-like receptor 3 Beyaert, R, Staal, J, Vercammen, E	Clin Microbiol Rev	2008
19627256	Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins O'Neill, LA, Carpenter, S	Biochem J	2009