Reactome | Synthesis of PIPs at the early endosome membrane

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Synthesis of PIPs at the early endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
created	[InstanceEdit:1660522] Williams, MG, 2011-10-13
dbId	1660516
displayName	Synthesis of PIPs at the early endosome membrane
doi	10.3180/R-HSA-1660516.6
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483255] PI Metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20474] phosphatidylinositol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Homo sapiens [Reaction:R-HSA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Homo sapiens [Reaction:R-HSA-1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676174] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676105] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Homo sapiens [Reaction:R-HSA-6809680] MTMR12 binds MTM1 - Homo sapiens [Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Homo sapiens [Reaction:R-HSA-6809707] MTMR12 binds MTMR2 - Homo sapiens [Reaction:R-HSA-1675974] PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Homo sapiens [Reaction:R-HSA-6810030] MTMR2 binds MTMR10 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:1460276] ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality [LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1675786] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes [LiteratureReference:1675857] Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking [LiteratureReference:1675904] Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors [LiteratureReference:1676059] Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Synthesis of PIPs at the early endosome membrane
orthologousEvent	[Pathway:R-PFA-1660516] Synthesis of PIPs at the early endosome membrane - Plasmodium falciparum [Pathway:R-SCE-1660516] Synthesis of PIPs at the early endosome membrane - Saccharomyces cerevisiae [Pathway:R-SPO-1660516] Synthesis of PIPs at the early endosome membrane - Schizosaccharomyces pombe [Pathway:R-DDI-1660516] Synthesis of PIPs at the early endosome membrane - Dictyostelium discoideum [Pathway:R-CEL-1660516] Synthesis of PIPs at the early endosome membrane - Caenorhabditis elegans [Pathway:R-DME-1660516] Synthesis of PIPs at the early endosome membrane - Drosophila melanogaster [Pathway:R-GGA-1660516] Synthesis of PIPs at the early endosome membrane - Gallus gallus [Pathway:R-XTR-1660516] Synthesis of PIPs at the early endosome membrane - Xenopus tropicalis [Pathway:R-DRE-1660516] Synthesis of PIPs at the early endosome membrane - Danio rerio [Pathway:R-SSC-1660516] Synthesis of PIPs at the early endosome membrane - Sus scrofa [Pathway:R-BTA-1660516] Synthesis of PIPs at the early endosome membrane - Bos taurus [Pathway:R-CFA-1660516] Synthesis of PIPs at the early endosome membrane - Canis familiaris [Pathway:R-RNO-1660516] Synthesis of PIPs at the early endosome membrane - Rattus norvegicus [Pathway:R-MMU-1660516] Synthesis of PIPs at the early endosome membrane - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
revised	[InstanceEdit:8979301] Orlic-Milacic, Marija, 2017-02-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1660516
summation	[Summation:1676188] At the early endosome membrane, phosphatidylinositol 3,5-bis...
updateTrackers	[UpdateTracker:9783416] Update Tracker - [Pathway:1660516] Synthesis of PIPs at the early endosome membrane - v56:[addHasEvent] [UpdateTracker:9781736] Update Tracker - [Pathway:1660516] Synthesis of PIPs at the early endosome membrane - v60:[addHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9783416] Update Tracker - [Pathway:1660516] Synthesis of PIPs at the early endosome membrane - v56:[addHasEvent] [UpdateTracker:9781736] Update Tracker - [Pathway:1660516] Synthesis of PIPs at the early endosome membrane - v60:[addHasEvent]
(hasEvent)	[Pathway:R-HSA-1483255] PI Metabolism

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