Reactome | PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane

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PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806278] 1-phosphatidylinositol-3-phosphate 5-kinase activity of PIKFYVE:VAC14:FIG4 [early endosome membrane]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:12667425] RHEA:13609
dbId	1676168
displayName	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676105] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane - Homo sapiens [BlackBoxEvent:R-HSA-1675896] PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane - Homo sapiens [Reaction:R-HSA-1676174] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane - Homo sapiens
inferredFrom	[Reaction:R-NUL-1675886] PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1806200] PI3P [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1675786] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes [LiteratureReference:1675955] PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin [LiteratureReference:1675790] Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex [LiteratureReference:1676068] Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806205] PI(3,5)P2 [early endosome membrane]
precedingEvent	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676174] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676168
summation	[Summation:1675993] At the early endosome membrane, the PAS complex, consisting ...

Referrals

(hasEvent)	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane
(precedingEvent)	[Reaction:R-HSA-1676105] PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane [BlackBoxEvent:R-HSA-1675896] PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane [Reaction:R-HSA-1676174] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
(inferredTo)	[Reaction:R-NUL-1675886] PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane