Reactome | PI3P is dephosphorylated to PI by MTM1:MTMR12

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PI3P is dephosphorylated to PI by MTM1:MTMR12 Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:6809714] phosphatidylinositol-3-phosphate phosphatase activity of MTM1:MTMR12 [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:6809713] Orlic-Milacic, Marija, 2015-11-12
crossReference	[DatabaseIdentifier:12667427] RHEA:12316
dbId	6809720
displayName	PI3P is dephosphorylated to PI by MTM1:MTMR12
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806200] PI3P [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809715] Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate [LiteratureReference:6809685] Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP [LiteratureReference:6809739] Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PI3P is dephosphorylated to PI by MTM1:MTMR12
orthologousEvent	[Reaction:R-SCE-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Saccharomyces cerevisiae [Reaction:R-SPO-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Schizosaccharomyces pombe [Reaction:R-DDI-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Dictyostelium discoideum [Reaction:R-CEL-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Caenorhabditis elegans [Reaction:R-DME-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Drosophila melanogaster [Reaction:R-GGA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Gallus gallus [Reaction:R-DRE-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Danio rerio [Reaction:R-SSC-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Sus scrofa [Reaction:R-BTA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Bos taurus [Reaction:R-CFA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Canis familiaris [Reaction:R-RNO-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Rattus norvegicus [Reaction:R-MMU-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806199] PI [early endosome membrane]
precedingEvent	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676174] PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Homo sapiens [Reaction:R-HSA-6809680] MTMR12 binds MTM1 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809720
summation	[Summation:6809717] Binding of MTMR12 to MTM1 enhances phosphatidylinositol-3-ph...

Referrals

(hasEvent)

[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane

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