Reactome | MTMR12 binds MTM1

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MTMR12 binds MTM1 Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:9959984] phosphatase activator activity of MTMR12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6809684] Orlic-Milacic, Marija, 2015-11-12
dbId	6809680
displayName	MTMR12 binds MTM1
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604646] MTM1 [cytosol] [EntityWithAccessionedSequence:R-HSA-6809657] MTMR12 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809685] Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP [LiteratureReference:6809739] Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish [LiteratureReference:6809715] Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	MTMR12 binds MTM1
orthologousEvent	[Reaction:R-SCE-6809680] MTMR12 binds MTM1 - Saccharomyces cerevisiae [Reaction:R-SPO-6809680] MTMR12 binds MTM1 - Schizosaccharomyces pombe [Reaction:R-DDI-6809680] MTMR12 binds MTM1 - Dictyostelium discoideum [Reaction:R-CEL-6809680] MTMR12 binds MTM1 - Caenorhabditis elegans [Reaction:R-DME-6809680] MTMR12 binds MTM1 - Drosophila melanogaster [Reaction:R-GGA-6809680] MTMR12 binds MTM1 - Gallus gallus [Reaction:R-DRE-6809680] MTMR12 binds MTM1 - Danio rerio [Reaction:R-SSC-6809680] MTMR12 binds MTM1 - Sus scrofa [Reaction:R-BTA-6809680] MTMR12 binds MTM1 - Bos taurus [Reaction:R-CFA-6809680] MTMR12 binds MTM1 - Canis familiaris [Reaction:R-RNO-6809680] MTMR12 binds MTM1 - Rattus norvegicus [Reaction:R-MMU-6809680] MTMR12 binds MTM1 - Mus musculus
output	[Complex:R-HSA-6809679] MTM1:MTMR12 [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809680
summation	[Summation:6809682] MTM1 forms a complex with MTMR12 (3 PAP), an enzymatically i...
updateTrackers	[UpdateTracker:9964620] Update Tracker - [Reaction:6809680] MTMR12 binds MTM1 - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964620] Update Tracker - [Reaction:6809680] MTMR12 binds MTM1 - v94:[removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12
(hasEvent)	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane

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