Reactome | PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane

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PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806222] 1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:12667457] RHEA:12709
dbId	1675939
displayName	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Homo sapiens [Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Homo sapiens [Reaction:R-HSA-1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1806199] PI [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675792] The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles [LiteratureReference:1675904] Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors [LiteratureReference:1675968] Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex [LiteratureReference:1675846] A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system [LiteratureReference:1675786] Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
orthologousEvent	[Reaction:R-PFA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Plasmodium falciparum [Reaction:R-DDI-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Dictyostelium discoideum [Reaction:R-SCE-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Schizosaccharomyces pombe [Reaction:R-CEL-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Caenorhabditis elegans [Reaction:R-DME-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Drosophila melanogaster [Reaction:R-GGA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Gallus gallus [Reaction:R-XTR-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Xenopus tropicalis [Reaction:R-DRE-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Danio rerio [Reaction:R-SSC-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Sus scrofa [Reaction:R-BTA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Bos taurus [Reaction:R-CFA-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Canis familiaris [Reaction:R-RNO-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Rattus norvegicus [Reaction:R-MMU-1675939] PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806200] PI3P [early endosome membrane]
precedingEvent	[Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1675939
summation	[Summation:1675828] At the early endosome membrane, phosphatidylinositol 3-kinas...

Referrals

(precedingEvent)	[Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 [Reaction:R-HSA-1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane [Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane
(hasEvent)	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane

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