Reactome | PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane

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PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806261] 1-phosphatidylinositol-4-phosphate 3-kinase activity of PIK3C2A:Ca2+/Mg2+ [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1676206
displayName	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1806180] PI4P [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676205] PI3KC2?, a class II PI3K, is required for dynamin-independent internalization pathways [LiteratureReference:1675904] Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
orthologousEvent	[Reaction:R-DDI-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Dictyostelium discoideum [Reaction:R-CEL-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Caenorhabditis elegans [Reaction:R-DME-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Drosophila melanogaster [Reaction:R-GGA-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Gallus gallus [Reaction:R-XTR-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Xenopus tropicalis [Reaction:R-DRE-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Danio rerio [Reaction:R-SSC-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Sus scrofa [Reaction:R-BTA-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Bos taurus [Reaction:R-CFA-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Canis familiaris [Reaction:R-RNO-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Rattus norvegicus [Reaction:R-MMU-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-1806238] PI(3,4)P2 [early endosome membrane]
precedingEvent	[Reaction:R-HSA-1675974] PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676206
summation	[Summation:1675958] At the early endosome membrane, phosphatidylinositol-4-phosp...

Referrals

(hasEvent)	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane
(precedingEvent)	[Reaction:R-HSA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane