Reactome | PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806174] phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
dbId	1676162
displayName	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 - Homo sapiens [Reaction:R-HSA-1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806238] PI(3,4)P2 [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1676179] The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase [LiteratureReference:1676120] The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family [LiteratureReference:1675803] The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
orthologousEvent	[Reaction:R-CEL-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Caenorhabditis elegans [Reaction:R-DME-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Drosophila melanogaster [Reaction:R-GGA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Gallus gallus [Reaction:R-XTR-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Xenopus tropicalis [Reaction:R-DRE-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Danio rerio [Reaction:R-SSC-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Sus scrofa [Reaction:R-BTA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Bos taurus [Reaction:R-CFA-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Canis familiaris [Reaction:R-RNO-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Rattus norvegicus [Reaction:R-MMU-1676162] PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806200] PI3P [early endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-1675834] PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane - Homo sapiens [Reaction:R-HSA-1676206] PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676162
summation	[Summation:1675978] At the early endosome membrane, type I (INPP4A) (Norris et a...

Referrals

(precedingEvent)	[Reaction:R-HSA-6809720] PI3P is dephosphorylated to PI by MTM1:MTMR12 [Reaction:R-HSA-1676168] PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane [Reaction:R-HSA-1676141] PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane
(hasEvent)	[Pathway:R-HSA-1660516] Synthesis of PIPs at the early endosome membrane

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