Reactome | DLL1 [plasma membrane]

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DLL1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2731152] DLL1:NOTCH1 HD domain mutant fragments [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 - Homo sapiens [Reaction:R-HSA-157145] NOTCH3 binds DLL1 - Homo sapiens [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 - Homo sapiens [Reaction:R-HSA-1980048] DLL1 binds NOTCH2 - Homo sapiens [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 - Homo sapiens [Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1 - Homo sapiens [Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1 - Homo sapiens
created	[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
dbId	157089
displayName	DLL1 [plasma membrane]
endCoordinate	723
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-DRE-157089] dla [plasma membrane] - Danio rerio [EntityWithAccessionedSequence:R-DME-157089] Delta [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-157089-2] C901 [plasma membrane] - Drosophila melanogaster [DefinedSet:R-DME-157089-3] Homologues of DLL1 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-157089] DLL1 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-157089-2] lin-12 [plasma membrane] - Caenorhabditis elegans [DefinedSet:R-CEL-157089-3] Homologues of DLL1 [plasma membrane] - Caenorhabditis elegans
markingReferences	[MarkerReference:9731167] DLL1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
maxDepth	1
memberOf	[DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2032259] Orlic-Milacic, M, 2012-01-06
name	DLL1 Delta 1 ligand
producedByEvent	[BlackBoxEvent:R-HSA-9832209] Expression of DLL1 during nephron development - Homo sapiens [BlackBoxEvent:R-HSA-9023351] DLL1 gene expression is inhibited by MECP2 - Homo sapiens [BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm - Homo sapiens [BlackBoxEvent:R-HSA-9825275] Expression of DLL1 in presomitic mesoderm - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:O00548] UniProt:O00548 DLL1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-157089
startCoordinate	18
updateTrackers	[UpdateTracker:9871533] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v40:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9871157] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v39:[addName] [UpdateTracker:9867674] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v25:[modifyName]

Referrals

(hasComponent)	[Complex:R-HSA-2731152] DLL1:NOTCH1 HD domain mutant fragments [extracellular region] [Complex:R-HSA-1911557] DLL1:NOTCH1 [plasma membrane] [Complex:R-HSA-157136] DLL1:NOTCH3 [plasma membrane] [Complex:R-HSA-1980050] DLL1:NOTCH2 [plasma membrane] [Complex:R-HSA-2768988] DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2900746] DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2902215] DLL1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] [Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane]
(input)	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 [Reaction:R-HSA-157145] NOTCH3 binds DLL1 [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 [Reaction:R-HSA-1980048] DLL1 binds NOTCH2 [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 [Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1 [Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1
(output)	[BlackBoxEvent:R-HSA-9832209] Expression of DLL1 during nephron development [BlackBoxEvent:R-HSA-9023351] DLL1 gene expression is inhibited by MECP2 [BlackBoxEvent:R-HSA-9793921] Expression of DLL1 in paraxial mesoderm [BlackBoxEvent:R-HSA-9825275] Expression of DLL1 in presomitic mesoderm
(hasMember)	[DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] [CandidateSet:R-HSA-9911710] DLL1, (DLL4, JAG1, JAG2) [plasma membrane]
(entityOnOtherCell)	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 [Complex:R-HSA-2902223] Ub-DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region] [Complex:R-HSA-2731152] DLL1:NOTCH1 HD domain mutant fragments [extracellular region] [Complex:R-HSA-2737729] Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] [Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane] [Complex:R-HSA-1911557] DLL1:NOTCH1 [plasma membrane] [Complex:R-HSA-9013093] Ub-DLL1:NOTCH3 [plasma membrane] [Complex:R-HSA-9013281] Ub-DLL1:NOTCH3(40-1628) [plasma membrane] [Complex:R-HSA-157136] DLL1:NOTCH3 [plasma membrane] [Reaction:R-HSA-157145] NOTCH3 binds DLL1 [Reaction:R-HSA-1980039] NOTCH1 binds DLL1 [Complex:R-HSA-1980050] DLL1:NOTCH2 [plasma membrane] [Reaction:R-HSA-1980048] DLL1 binds NOTCH2 [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 [Complex:R-HSA-2768988] DLL1:NOTCH1 PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2769006] Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2900746] DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2900763] Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Complex:R-HSA-2902215] DLL1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] [Complex:R-HSA-2902216] Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane] [Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1 [Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1
(marker)	[MarkerReference:9731167] DLL1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
(proteinMarker)	[Cell:R-HSA-9725559] keratinocyte stem cell of skin epidermis basal layer
(updatedInstance)	[UpdateTracker:9871533] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v40:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9871157] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v39:[addName] [UpdateTracker:9867674] Update Tracker - [EntityWithAccessionedSequence:157089] DLL1 [plasma membrane] - v25:[modifyName]

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