Reactome | keratinocyte stem cell of skin epidermis basal layer

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keratinocyte stem cell of skin epidermis basal layer Show undefined attributes

cellType	[CellType:9725586] stem cell of epidermis
consumedByEvent	[CellDevelopmentStep:R-HSA-9725621] Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis - Homo sapiens
created	[InstanceEdit:9725578] Orlic-Milacic, Marija, 2021-03-29
dbId	9725559
displayName	keratinocyte stem cell of skin epidermis basal layer
inDisease	false
literatureReference	[LiteratureReference:9725604] Enrichment and identification of human 'fetal' epidermal stem cells [LiteratureReference:9725570] Epidermal stem cells: markers, patterning and the control of stem cell fate [LiteratureReference:9725553] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis [LiteratureReference:9725572] Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis [LiteratureReference:9725624] The type I keratin 19 possesses distinct and context-dependent assembly properties [LiteratureReference:9725610] [Epidermal growth factor induce the epithelial stem cell island formation in the regenerated epidermis] [LiteratureReference:9725580] p63 expression in normal skin and usual cutaneous carcinomas [LiteratureReference:9861113] Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment [LiteratureReference:9861119] Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid [LiteratureReference:9861120] Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis [LiteratureReference:9840015] Single cell transcriptomics of human epidermis identifies basal stem cell transition states
markerReference	[MarkerReference:9839478] AQP3 [plasma membrane] Functional expression of AQP3 in human skin epidermis and reconstructed epidermis [MarkerReference:9731956] CSPG4 mRNA [cytosol] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence [MarkerReference:9731159] LRIG1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence [MarkerReference:9861234] COL17A1 mRNA [cytosol] Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment [MarkerReference:9820691] HC-ABCG2 [plasma membrane] Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis [MarkerReference:9731954] ITGA6(24-1130) [plasma membrane] Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype [MarkerReference:9725587] TP63 [nucleoplasm] Enrichment and identification of human 'fetal' epidermal stem cells [MarkerReference:9725565] KRT19 [cytosol] The type I keratin 19 possesses distinct and context-dependent assembly properties [MarkerReference:9725566] CSPG4 [plasma membrane] Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis [MarkerReference:9731167] DLL1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence [MarkerReference:9861115] COL17A1(1-1497) [endoplasmic reticulum lumen] Single cell transcriptomics of human epidermis identifies basal stem cell transition states [MarkerReference:9861125] LGALS7 [cytosol] Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid [MarkerReference:9731943] LRIG1 mRNA [cytosol] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence [MarkerReference:9725614] ITGB1 [plasma membrane] Enrichment and identification of human 'fetal' epidermal stem cells [MarkerReference:9731950] ITGB4 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence [MarkerReference:9725583] NUMB [plasma membrane] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis [MarkerReference:9839464] YAP1 [nucleoplasm] Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
maxDepth	2
modified	[InstanceEdit:9863939] Matthews, Lisa, 2024-03-06
name	keratinocyte stem cell of skin epidermis basal layer keratinocyte stem cell of skin epidermis stratum basale
organ	[Anatomy:9725577] skin of body
proteinMarker	[EntityWithAccessionedSequence:R-HSA-9734933] CSPG4 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-204439] ITGA6(24-1130) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-57596] ITGB1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-215947] ITGB4 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6809617] KRT19 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-197745] LRIG1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-443595] NUMB [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2997585] TP63 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-917929] HC-ABCG2 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1253322] YAP1 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-431723] AQP3 [plasma membrane] - Homo sapiens
rNAMarker	[EntityWithAccessionedSequence:R-HSA-9731951] CSPG4 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9731949] LRIG1 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9861231] COL17A1 mRNA [cytosol] - Homo sapiens
schemaClass	Cell
species	[Species:48887] Homo sapiens
stId	R-HSA-9725559
tissue	[Anatomy:9725551] skin epidermis
tissueLayer	[Anatomy:9725619] stratum basale of epidermis

Referrals

(input)

[CellDevelopmentStep:R-HSA-9725621] Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis

(cell)

[MarkerReference:9839478] AQP3 [plasma membrane] Functional expression of AQP3 in human skin epidermis and reconstructed epidermis
[MarkerReference:9731956] CSPG4 mRNA [cytosol] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
[MarkerReference:9731159] LRIG1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
[MarkerReference:9861234] COL17A1 mRNA [cytosol] Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment
[MarkerReference:9820691] HC-ABCG2 [plasma membrane] Breast cancer resistance protein identifies clonogenic keratinocytes in human interfollicular epidermis
[MarkerReference:9731954] ITGA6(24-1130) [plasma membrane] Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype
[MarkerReference:9725587] TP63 [nucleoplasm] Enrichment and identification of human 'fetal' epidermal stem cells
[MarkerReference:9725565] KRT19 [cytosol] The type I keratin 19 possesses distinct and context-dependent assembly properties
[MarkerReference:9725566] CSPG4 [plasma membrane] Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis
[MarkerReference:9731167] DLL1 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
[MarkerReference:9861115] COL17A1(1-1497) [endoplasmic reticulum lumen] Single cell transcriptomics of human epidermis identifies basal stem cell transition states
[MarkerReference:9861125] LGALS7 [cytosol] Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid
[MarkerReference:9731943] LRIG1 mRNA [cytosol] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
[MarkerReference:9725614] ITGB1 [plasma membrane] Enrichment and identification of human 'fetal' epidermal stem cells
[MarkerReference:9731950] ITGB4 [plasma membrane] Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence
[MarkerReference:9725583] NUMB [plasma membrane] Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis
[MarkerReference:9839464] YAP1 [nucleoplasm] Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

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