Reactome | PC is exchanged with PI by PITPNB

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PC is exchanged with PI by PITPNB Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:9855941] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9855945] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
dbId	1483219
displayName	PC is exchanged with PI by PITPNB
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483196] PI and PC transport between ER and Golgi membranes - Homo sapiens
followingEvent	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens [Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens [Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens [Reaction:R-HSA-1483229] PI:PITPNB is transported from the ER membrane to the Golgi membrane - Homo sapiens [Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6 - Homo sapiens [Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens
input	[Complex:R-HSA-1524110] PC:PITPNB [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1483105] Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells [LiteratureReference:1483109] Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum [LiteratureReference:1483200] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine [LiteratureReference:1483223] Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms [LiteratureReference:1483130] Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association [LiteratureReference:1483188] Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PC is exchanged with PI by PITPNB
orthologousEvent	[Reaction:R-GGA-1483219] PC is exchanged with PI by PITPNB - Gallus gallus [Reaction:R-DDI-1483219] PC is exchanged with PI by PITPNB - Dictyostelium discoideum [Reaction:R-XTR-1483219] PC is exchanged with PI by PITPNB - Xenopus tropicalis [Reaction:R-DME-1483219] PC is exchanged with PI by PITPNB - Drosophila melanogaster [Reaction:R-CEL-1483219] PC is exchanged with PI by PITPNB - Caenorhabditis elegans [Reaction:R-SSC-1483219] PC is exchanged with PI by PITPNB - Sus scrofa [Reaction:R-PFA-1483219] PC is exchanged with PI by PITPNB - Plasmodium falciparum [Reaction:R-BTA-1483219] PC is exchanged with PI by PITPNB - Bos taurus [Reaction:R-CFA-1483219] PC is exchanged with PI by PITPNB - Canis familiaris [Reaction:R-DRE-1483219] PC is exchanged with PI by PITPNB - Danio rerio [Reaction:R-RNO-1483219] PC is exchanged with PI by PITPNB - Rattus norvegicus [Reaction:R-MMU-1483219] PC is exchanged with PI by PITPNB - Mus musculus
output	[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane] [Complex:R-HSA-1524117] PI:PITPNB [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483211] PC:PITPNB is transported from the Golgi membrane to the ER membrane - Homo sapiens [Reaction:R-HSA-1482976] CDP-DAG is converted to PI by CDIPT - Homo sapiens [Reaction:R-HSA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens [Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens [Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:9860910] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1483219
summation	[Summation:1482923] At the ER membrane, phosphatidylcholine (PC) is exchanged fo...
updateTrackers	[UpdateTracker:9863958] Update Tracker - [Reaction:1483219] PC is exchanged with PI by PITPNB - v88:[addCatalystActivity, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] [Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] [Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C [Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] [Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 [Reaction:R-HSA-1483229] PI:PITPNB is transported from the ER membrane to the Golgi membrane [Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6
(hasEvent)	[Pathway:R-HSA-1483196] PI and PC transport between ER and Golgi membranes
(updatedInstance)	[UpdateTracker:9863958] Update Tracker - [Reaction:1483219] PC is exchanged with PI by PITPNB - v88:[addCatalystActivity, modifyText]

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