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Schema
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Entries
PC is hydrolyzed to PA and choline by PLD1/2
Show undefined attributes
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authored
[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity
[CatalystActivity:1500629] phospholipase D activity of PLD1/2 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1483214] Williams, MG, 2011-08-12
dbId
1483182
displayName
PC is hydrolyzed to PA and choline by PLD1/2
edited
[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf
[Pathway:R-HSA-1483166] Synthesis of PA - Homo sapiens
followingEvent
[Reaction:R-HSA-1483004] Cho is phosphorylated to PCho by CHK dimer - Homo sapiens
[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN - Homo sapiens
[Reaction:R-HSA-264622] Cho is acetylated to AcCho by CHAT - Homo sapiens
[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1 - Homo sapiens
[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Homo sapiens
[Reaction:R-HSA-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1483192] Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family
[LiteratureReference:1483024] Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
PC is hydrolyzed to PA and choline by PLD1/2
orthologousEvent
[Reaction:R-MMU-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Mus musculus
[Reaction:R-RNO-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Rattus norvegicus
[Reaction:R-BTA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Bos taurus
[Reaction:R-CFA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Canis familiaris
[Reaction:R-SSC-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Sus scrofa
[Reaction:R-XTR-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Xenopus tropicalis
[Reaction:R-DDI-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Dictyostelium discoideum
[Reaction:R-GGA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Gallus gallus
[Reaction:R-SCE-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Saccharomyces cerevisiae
[Reaction:R-SPO-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Schizosaccharomyces pombe
[Reaction:R-CEL-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Caenorhabditis elegans
[Reaction:R-DME-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Drosophila melanogaster
output
[SimpleEntity:R-ALL-264618] Cho [cytosol]
[SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
[Reaction:R-HSA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1483182
summation
[Summation:1483207] Phosphatidylcholine (PC) is hydrolyzed to phosphatidic acid ...
Referrals
(hasEvent)
[Pathway:R-HSA-1483166] Synthesis of PA
(precedingEvent)
[Reaction:R-HSA-264622] Cho is acetylated to AcCho by CHAT
[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1
[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1]
[Reaction:R-HSA-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A
[Reaction:R-HSA-1483004] Cho is phosphorylated to PCho by CHK dimer
[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN
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