Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[5]

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PC is hydrolyzed to 1-acyl LPC by PLA2[5] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524124] A2-type glycerophospholipase activity of PLA2(5) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482856
displayName	PC is hydrolyzed to 1-acyl LPC by PLA2[5]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens [Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482693] The identification of a phospholipase B precursor in human neutrophils [LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms [LiteratureReference:378474] A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP [LiteratureReference:1482518] Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 [LiteratureReference:1482841] Molecular characterization of cytosolic phospholipase A2-beta [LiteratureReference:1482573] A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 [LiteratureReference:1482885] Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 [LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482909] Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin [LiteratureReference:1482893] Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity [LiteratureReference:1482851] Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 [LiteratureReference:1482872] The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene [LiteratureReference:1482854] Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PC is hydrolyzed to 1-acyl LPC by PLA2[5]
orthologousEvent	[Reaction:R-MMU-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Mus musculus [Reaction:R-RNO-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Rattus norvegicus [Reaction:R-CFA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Canis familiaris [Reaction:R-BTA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Bos taurus [Reaction:R-GGA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Gallus gallus [Reaction:R-CEL-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Caenorhabditis elegans [Reaction:R-DME-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Drosophila melanogaster [Reaction:R-XTR-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Xenopus tropicalis [Reaction:R-SCE-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Saccharomyces cerevisiae [Reaction:R-SPO-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Schizosaccharomyces pombe [Reaction:R-DDI-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Dictyostelium discoideum [Reaction:R-DRE-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Danio rerio [Reaction:R-SSC-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Sus scrofa
output	[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens [Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens [Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens [Reaction:R-HSA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482856
summation	[Summation:1482876] At the endoplasmic reticulum (ER) membrane, phosphatidylchol...

Referrals

(hasEvent)	[Pathway:R-HSA-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT [Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]

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