Reactome | PC is hydrolyzed to 1-acyl LPC by PLA2[6]

Schema > Reaction > Entries

PC is hydrolyzed to 1-acyl LPC by PLA2[6] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524115] A2-type glycerophospholipase activity of PLA2(6) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId	1482816
displayName	PC is hydrolyzed to 1-acyl LPC by PLA2[6]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens [Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Homo sapiens [Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482791] Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid [LiteratureReference:1482657] Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 [LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms [LiteratureReference:1482573] A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2 [LiteratureReference:1482885] Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2 [LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482805] Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PC is hydrolyzed to 1-acyl LPC by PLA2[6]
orthologousEvent	[Reaction:R-RNO-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Rattus norvegicus [Reaction:R-MMU-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Mus musculus [Reaction:R-CFA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Canis familiaris [Reaction:R-BTA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Bos taurus [Reaction:R-CEL-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Caenorhabditis elegans [Reaction:R-XTR-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Xenopus tropicalis [Reaction:R-SCE-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Saccharomyces cerevisiae [Reaction:R-SPO-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Schizosaccharomyces pombe [Reaction:R-DDI-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Dictyostelium discoideum [Reaction:R-DRE-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Danio rerio [Reaction:R-SSC-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Sus scrofa [Reaction:R-GGA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Gallus gallus
output	[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens [Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens [Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens [Reaction:R-HSA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482816
summation	[Summation:1482758] At the endoplasmic reticulum (ER) membrane, phosphatidylchol...

Referrals

(hasEvent)	[Pathway:R-HSA-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT [Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C [Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]

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