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Entries
PC is hydrolyzed to 1-acyl LPC by PLA2[6]
Show undefined attributes
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authored
[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity
[CatalystActivity:1524115] phospholipase A2 activity of PLA2(6) [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId
1482816
displayName
PC is hydrolyzed to 1-acyl LPC by PLA2[6]
edited
[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
[Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Homo sapiens
[Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1482791] Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid
[LiteratureReference:1482657] Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2
[LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms
[LiteratureReference:1482573] A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2
[LiteratureReference:1482885] Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
[LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)
[LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
[LiteratureReference:1482805] Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
PC is hydrolyzed to 1-acyl LPC by PLA2[6]
orthologousEvent
[Reaction:R-MMU-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Mus musculus
[Reaction:R-RNO-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Rattus norvegicus
[Reaction:R-BTA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Bos taurus
[Reaction:R-CFA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Canis familiaris
[Reaction:R-SSC-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Sus scrofa
[Reaction:R-SCE-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Saccharomyces cerevisiae
[Reaction:R-SPO-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Schizosaccharomyces pombe
[Reaction:R-DDI-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Dictyostelium discoideum
[Reaction:R-CEL-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Caenorhabditis elegans
[Reaction:R-DME-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Drosophila melanogaster
[Reaction:R-XTR-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Xenopus tropicalis
[Reaction:R-DRE-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Danio rerio
[Reaction:R-GGA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Gallus gallus
output
[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens
[Reaction:R-HSA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1482816
summation
[Summation:1482758] At the endoplasmic reticulum (ER) membrane, phosphatidylchol...
Referrals
(hasEvent)
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC
(precedingEvent)
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT
[Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
[Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
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