Reactome | 1-acyl LPI is acylated to PI by MBOAT7

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1-acyl LPI is acylated to PI by MBOAT7 Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524032] 1-acylglycerol-3-phosphate O-acyltransferase activity of MBOAT7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
crossReference	[DatabaseIdentifier:12667430] RHEA:33195
dbId	1482598
displayName	1-acyl LPI is acylated to PI by MBOAT7
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1482922] Acyl chain remodelling of PI - Homo sapiens
followingEvent	[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Homo sapiens [Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Homo sapiens [Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens [Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Homo sapiens [Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
input	[SimpleEntity:R-ALL-1498733] 1-acyl LPI [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils [LiteratureReference:1482673] Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	1-acyl LPI is acylated to PI by MBOAT7
orthologousEvent	[Reaction:R-SSC-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Sus scrofa [Reaction:R-CEL-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Caenorhabditis elegans [Reaction:R-DME-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Drosophila melanogaster [Reaction:R-XTR-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Xenopus tropicalis [Reaction:R-SCE-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Saccharomyces cerevisiae [Reaction:R-SPO-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Schizosaccharomyces pombe [Reaction:R-DDI-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Dictyostelium discoideum [Reaction:R-DRE-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Danio rerio [Reaction:R-BTA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Bos taurus [Reaction:R-CFA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Canis familiaris [Reaction:R-RNO-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Rattus norvegicus [Reaction:R-MMU-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Homo sapiens [Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482598
summation	[Summation:1482603] At the endoplasmic reticulum (ER) membrane, lysophospholipid...

Referrals

(hasEvent)	[Pathway:R-HSA-1482922] Acyl chain remodelling of PI
(precedingEvent)	[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB [Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane [Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] [Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12]

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