Reactome | PI4P is dephosphorylated to PI by SACM1L at the ER membrane

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PI4P is dephosphorylated to PI by SACM1L at the ER membrane Show undefined attributes

authored	[InstanceEdit:1678579] Williams, MG, 2011-10-18
catalystActivity	[CatalystActivity:1806179] phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1676083] Williams, MG, 2011-10-17
crossReference	[DatabaseIdentifier:12667429] RHEA:55652
dbId	1676124
displayName	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens [Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Homo sapiens [Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Homo sapiens [Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Homo sapiens [Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675768] The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PI4P is dephosphorylated to PI by SACM1L at the ER membrane
orthologousEvent	[Reaction:R-PFA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Plasmodium falciparum [Reaction:R-SSC-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Sus scrofa [Reaction:R-CEL-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Caenorhabditis elegans [Reaction:R-DME-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Drosophila melanogaster [Reaction:R-SCE-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Dictyostelium discoideum [Reaction:R-DRE-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Danio rerio [Reaction:R-BTA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Bos taurus [Reaction:R-CFA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Canis familiaris [Reaction:R-RNO-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Rattus norvegicus [Reaction:R-MMU-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Mus musculus [Reaction:R-GGA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Gallus gallus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens [Reaction:R-HSA-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane - Homo sapiens [Reaction:R-HSA-8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane - Homo sapiens [Reaction:R-HSA-8867876] OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247963] Wakelam, Michael, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1676124
summation	[Summation:1676026] At the endoplasmic reticulum (ER) membrane, transmembrane pr...
updateTrackers	[UpdateTracker:9783624] Update Tracker - [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - v56:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783624] Update Tracker - [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - v56:[modifyText]
(hasEvent)	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)	[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB [Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] [Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] [Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] [Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane

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