PC is exchanged with PI by PITPNB

Stable Identifier
R-HSA-1483219
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the ER membrane, phosphatidylcholine (PC) is exchanged for phosphatidylinositol (PI) within the phosphatidylinositol transfer protein beta isoform (PITPNB) complex (Tilley et al. 2004, Yolder et al. 2001, Carvou et al. 2010, Schouten et al. 2002, Vordtriede et al. 2005, Shadan et al. 2008).

Literature References
PubMed ID Title Journal Year
18636990 Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells

Shadan, S, Holic, R, Carvou, N, Ee, P, Li, M, Murray-Rust, J, Cockcroft, S

Traffic 2008
11980708 Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association

Schouten, A, Agianian, B, Westerman, J, Kroon, J, Wirtz, KWA, Gros, P

EMBO J 2002
11104777 Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine

Yoder, MD, Thomas, LM, Tremblay, JM, Oliver, RL, Yarbrough, LR, Helmkamp GM, Jr

J Biol Chem 2001
20332109 Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum

Carvou, N, Holic, R, Li, M, Futter, C, Skippen, A, Cockcroft, S

J Cell Sci 2010
14962392 Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol

Tilley, SJ, Skippen, A, Murray-Rust, J, Swigart, PM, Stewart, A, Morgan, CP, Cockcroft, S, McDonald, NQ

Structure 2004
16274224 Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms

Vordtriede, PB, Doan, CN, Tremblay, JM, Helmkamp GM, Jr, Yoder, MD

Biochemistry 2005
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