Reactome | PC is exchanged with PI by PITPNB

PC is exchanged with PI by PITPNB

Stable Identifier

R-HSA-1483219

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - PI and PC transport between ER and Golgi membranes (Homo sapiens)
        
        PC is exchanged with PI by PITPNB (Homo sapiens)
    - PI Metabolism (Homo sapiens)
      - PI and PC transport between ER and Golgi membranes (Homo sapiens)
        
        PC is exchanged with PI by PITPNB (Homo sapiens)

General

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At the ER membrane, phosphatidylcholine (PC) is exchanged for phosphatidylinositol (PI) within the phosphatidylinositol transfer protein beta isoform (PITPNB) complex (Tilley et al. 2004, Yoder et al. 2001, Carvou et al. 2010, Schouten et al. 2002, Vordtriede et al. 2005, Shadan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
16274224	Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms Vordtriede, PB, Doan, CN, Tremblay, JM, Helmkamp GM, Jr, Yoder, MD	Biochemistry	2005
14962392	Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol Tilley, SJ, Skippen, A, Murray-Rust, J, Swigart, PM, Stewart, A, Morgan, CP, Cockcroft, S, McDonald, NQ	Structure	2004
20332109	Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum Carvou, N, Holic, R, Li, M, Futter, C, Skippen, A, Cockcroft, S	J Cell Sci	2010
11104777	Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine Yoder, MD, Thomas, LM, Tremblay, JM, Oliver, RL, Yarbrough, LR, Helmkamp GM, Jr	J Biol Chem	2001
18636990	Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells Shadan, S, Holic, R, Carvou, N, Ee, P, Li, M, Murray-Rust, J, Cockcroft, S	Traffic	2008
11980708	Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association Schouten, A, Agianian, B, Westerman, J, Kroon, J, Wirtz, KWA, Gros, P	EMBO J	2002