Reactome | CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane

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CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524063] diacylglycerol cholinephosphotransferase activity of CEPT1:Mg2+/Mn2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482967] Williams, MG, 2011-08-12
crossReference	[DatabaseIdentifier:12667436] RHEA:32939
dbId	1482961
displayName	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483191] Synthesis of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens [Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6 - Homo sapiens [Reaction:R-HSA-8858298] HRASLS transfer acyl group from PC to PE to form NAPE - Homo sapiens [Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens [Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens [Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens [Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
input	[SimpleEntity:R-ALL-1524060] CDP-Cho [cytosol] [SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482959] Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine [LiteratureReference:1482937] Cloning, genomic organization, and characterization of a human cholinephosphotransferase [LiteratureReference:1482954] PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) [LiteratureReference:1482958] The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
orthologousEvent	[Reaction:R-PFA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Plasmodium falciparum [Reaction:R-MMU-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Mus musculus [Reaction:R-RNO-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Rattus norvegicus [Reaction:R-DRE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Danio rerio [Reaction:R-CFA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Canis familiaris [Reaction:R-BTA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Bos taurus [Reaction:R-SSC-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Sus scrofa [Reaction:R-CEL-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Caenorhabditis elegans [Reaction:R-DME-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Drosophila melanogaster [Reaction:R-SCE-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Dictyostelium discoideum [Reaction:R-GGA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Gallus gallus
output	[SimpleEntity:R-ALL-109395] CMP [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1483081] PCho and CTP are condensed to CDP-Cho by PCYT1 dimer - Homo sapiens [Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN - Homo sapiens [Reaction:R-HSA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Homo sapiens [Reaction:R-HSA-1482654] 2-MAG is transacylated to DAG by PNPLA2/3 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482961
summation	[Summation:1482878] At the endoplasmic reticulum (ER) membrane, choline/ethanola...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-1483191] Synthesis of PC

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