Reactome | CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane

Stable Identifier

R-HSA-1482961

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane

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At the endoplasmic reticulum (ER) membrane, choline/ethanolaminephosphotransferase (CEPT1) converts CDP-choline (CDP-Cho) and diacylglycerol (DAG) to phosphatidylcholine (PC) and cytidine monophosphate (CMP) (Wright et al. 2002, Henneberry et al. 1999, Henneberry et al. 2002, Henneberry et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10893425	Cloning, genomic organization, and characterization of a human cholinephosphotransferase Henneberry, AL, McMaster, CR, Wistow, G	J Biol Chem	2000
12216837	PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1) Wright, MM, McMaster, CR	Lipids	2002
10191259	Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine Henneberry, AL, McMaster, CR	Biochem J	1999
12221122	The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity Henneberry, AL, Wright, MM, McMaster, CR	Mol Biol Cell	2002