Reactome | PA is dephosphorylated to DAG by LPIN

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PA is dephosphorylated to DAG by LPIN Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1500627] phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643903] phosphatidate phosphatase activity of LPIN [endoplasmic reticulum membrane] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1483214] Williams, MG, 2011-08-12
dbId	1483203
displayName	PA is dephosphorylated to DAG by LPIN
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483213] Synthesis of PE - Homo sapiens [Pathway:R-HSA-1483191] Synthesis of PC - Homo sapiens
followingEvent	[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens [Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:549163] Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns [LiteratureReference:549166] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PA is dephosphorylated to DAG by LPIN
orthologousEvent	[Reaction:R-XTR-1483203] PA is dephosphorylated to DAG by LPIN - Xenopus tropicalis [Reaction:R-PFA-1483203] PA is dephosphorylated to DAG by LPIN - Plasmodium falciparum [Reaction:R-MMU-1483203] PA is dephosphorylated to DAG by LPIN - Mus musculus [Reaction:R-RNO-1483203] PA is dephosphorylated to DAG by LPIN - Rattus norvegicus [Reaction:R-DRE-1483203] PA is dephosphorylated to DAG by LPIN - Danio rerio [Reaction:R-CFA-1483203] PA is dephosphorylated to DAG by LPIN - Canis familiaris [Reaction:R-BTA-1483203] PA is dephosphorylated to DAG by LPIN - Bos taurus [Reaction:R-SSC-1483203] PA is dephosphorylated to DAG by LPIN - Sus scrofa [Reaction:R-CEL-1483203] PA is dephosphorylated to DAG by LPIN - Caenorhabditis elegans [Reaction:R-DME-1483203] PA is dephosphorylated to DAG by LPIN - Drosophila melanogaster [Reaction:R-SCE-1483203] PA is dephosphorylated to DAG by LPIN - Saccharomyces cerevisiae [Reaction:R-SPO-1483203] PA is dephosphorylated to DAG by LPIN - Schizosaccharomyces pombe [Reaction:R-DDI-1483203] PA is dephosphorylated to DAG by LPIN - Dictyostelium discoideum [Reaction:R-GGA-1483203] PA is dephosphorylated to DAG by LPIN - Gallus gallus
output	[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens [Reaction:R-HSA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1483203
summation	[Summation:1482977] At the endoplasmic reticulum (ER) membrane, phosphatidate ph...

Referrals

(hasEvent)	[Pathway:R-HSA-1483213] Synthesis of PE [Pathway:R-HSA-1483191] Synthesis of PC
(precedingEvent)	[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane [Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1

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