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TAG is hydrolyzed to DAG by PNPLA2/3
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authored
[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity
[CatalystActivity:1500645] triglyceride lipase activity of PNPLA2/3 [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1482800] Williams, MG, 2011-08-12
dbId
1482777
displayName
TAG is hydrolyzed to DAG by PNPLA2/3
edited
[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf
[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG - Homo sapiens
followingEvent
[Reaction:R-HSA-1482889] DAG is acylated to TAG by DGAT1/2 - Homo sapiens
[Reaction:R-HSA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3 - Homo sapiens
[Reaction:R-HSA-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Homo sapiens
[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens
[Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-1500594] TAG [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1482692] Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
[LiteratureReference:1482706] A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
[LiteratureReference:1482888] Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
TAG is hydrolyzed to DAG by PNPLA2/3
orthologousEvent
[Reaction:R-MMU-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Mus musculus
[Reaction:R-PFA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Plasmodium falciparum
[Reaction:R-CEL-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Caenorhabditis elegans
[Reaction:R-DME-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Drosophila melanogaster
[Reaction:R-GGA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Gallus gallus
[Reaction:R-XTR-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Xenopus tropicalis
[Reaction:R-DRE-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Danio rerio
[Reaction:R-SSC-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Sus scrofa
[Reaction:R-BTA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Bos taurus
[Reaction:R-CFA-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Canis familiaris
[Reaction:R-RNO-1482777] TAG is hydrolyzed to DAG by PNPLA2/3 - Rattus norvegicus
output
[SimpleEntity:R-ALL-1500596] DAG [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1482889] DAG is acylated to TAG by DGAT1/2 - Homo sapiens
[Reaction:R-HSA-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3 - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1482777
summation
[Summation:1482774] At the endoplasmic reticulum (ER) membrane, triacylglycerol ...
Referrals
(hasEvent)
[Pathway:R-HSA-1482883] Acyl chain remodeling of DAG and TAG
(precedingEvent)
[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
[Reaction:R-HSA-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1
[Reaction:R-HSA-1482889] DAG is acylated to TAG by DGAT1/2
[Reaction:R-HSA-1482811] DAG is hydrolyzed to 2-MAG by PNPLA2/3
[Reaction:R-HSA-1482647] 2-MAG and DAG are transacylated to TAG by PNPLA2/3
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