Reactome | Transcription of E2F targets under negative control by DREAM complex

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Transcription of E2F targets under negative control by DREAM complex Show undefined attributes

authored	[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1362274] Orlic-Milacic, Marija, 2011-06-07
crossReference	[DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12819537] BioModels Database:BIOMD0000000700
dbId	1362277
displayName	Transcription of E2F targets under negative control by DREAM complex
eventOf	[Pathway:R-HSA-1538133] G0 and Early G1 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8964471] DREAM complex binds the CDC25A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - Homo sapiens [Reaction:R-HSA-8964498] DREAM complex binds the CDC6 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961619] CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex - Homo sapiens [Reaction:R-HSA-8964482] DREAM complex binds the E2F1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8964513] E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 - Homo sapiens [Reaction:R-HSA-8964465] DREAM complex binds the PCNA gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8961665] PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex - Homo sapiens [Reaction:R-HSA-8964492] DREAM complex binds the RBL1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8964525] RBL1 gene expression is repressed by the DREAM complex - Homo sapiens [Reaction:R-HSA-8964475] DREAM complex binds the TOP2A gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8964531] TOP2A gene gene expression is repressed by the DREAM complex - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Transcription of E2F targets under negative control by DREAM complex
precedingEvent	[Reaction:R-HSA-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1538129] MacPherson, D, 2011-08-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1362277
summation	[Summation:1362275] DREAM complex is evolutionarily conserved and is responsible...
updateTrackers	[UpdateTracker:9911035] Update Tracker - [Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex - v89:[modifyText]

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(updatedInstance)	[UpdateTracker:9911035] Update Tracker - [Pathway:1362277] Transcription of E2F targets under negative control by DREAM complex - v89:[modifyText]
(hasEvent)	[Pathway:R-HSA-1538133] G0 and Early G1