Reactome | Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence Show undefined attributes

author	[Person:1362241] Litovchick, L [Person:1362240] Sadasivam, S [Person:2084248] Florens, LA [Person:1362243] Zhu, X [Person:212893] Swanson, SK [Person:1362244] Velmurugan, S [Person:1362242] Chen, R [Person:212876] Washburn, MP [Person:442482] Liu, XS [Person:75758] DeCaprio, JA
created	[InstanceEdit:1362255] Orlic-Milacic, Marija, 2011-06-07
dbId	1362256
displayName	Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
journal	Mol Cell
modified	[InstanceEdit:8953782] D'Eustachio, Peter, 2016-12-27
pages	539-51
pubMedIdentifier	17531812
schemaClass	LiteratureReference
title	Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
url	http://www.ncbi.nlm.nih.gov/pubmed/17531812
volume	26
year	2007

Referrals

(literatureReference)

[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex
[BlackBoxEvent:R-HSA-8964531] TOP2A gene gene expression is repressed by the DREAM complex
[RegulationReference:9642902] Negative gene expression regulation by 'DREAM complex:TOP2A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[RegulationReference:9642359] Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[Reaction:R-HSA-8964465] DREAM complex binds the PCNA gene promoter
[Complex:R-HSA-8964464] DREAM complex:PCNA gene [nucleoplasm]
[BlackBoxEvent:R-HSA-8964513] E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2
[Reaction:R-HSA-8964482] DREAM complex binds the E2F1 gene promoter
[RegulationReference:9642011] Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[Complex:R-HSA-8964483] DREAM complex:E2F1 gene [nucleoplasm]
[BlackBoxEvent:R-HSA-8964525] RBL1 gene expression is repressed by the DREAM complex
[RegulationReference:9641974] Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[Reaction:R-HSA-8964492] DREAM complex binds the RBL1 gene promoter
[Complex:R-HSA-8964487] DREAM complex:RBL1 gene [nucleoplasm]
[Reaction:R-HSA-8964475] DREAM complex binds the TOP2A gene promoter
[Complex:R-HSA-8964478] DREAM complex:TOP2A gene [nucleoplasm]
[BlackBoxEvent:R-HSA-8961619] CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
[Reaction:R-HSA-8964498] DREAM complex binds the CDC6 gene promoter
[RegulationReference:9641835] Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[Complex:R-HSA-8964499] DREAM complex:CDC6 gene [nucleoplasm]
[BlackBoxEvent:R-HSA-188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex
[Reaction:R-HSA-8964471] DREAM complex binds the CDC25A gene promoter
[Reaction:R-HSA-1362261] p130 (RBL2) associates with MuvB to form DREAM complex
[RegulationReference:9642802] Negative gene expression regulation by 'DREAM complex:CDC25A gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[Complex:R-HSA-8964470] DREAM complex:CDC25A gene [nucleoplasm]
[Complex:R-HSA-1362264] DREAM complex [nucleoplasm]

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