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Schema
>
BlackBoxEvent
>
Entries
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2
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authored
[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8964511] Orlic-Milacic, Marija, 2017-02-17
dbId
8964513
displayName
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2
edited
[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
eventOf
[Pathway:R-HSA-1362300] Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 - Homo sapiens
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
inferredFrom
[BlackBoxEvent:R-MMU-8979012] E2f1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1 - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-6798348] E2F1 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[LiteratureReference:1362298] E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2
output
[EntityWithAccessionedSequence:R-HSA-68639] E2F1 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-8964482] DREAM complex binds the E2F1 gene promoter - Homo sapiens
[Reaction:R-HSA-8964550] The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter - Homo sapiens
regulatedBy
[NegativeGeneExpressionRegulation:R-HSA-8964514] Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:R-HSA-8964548] Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]'
regulationReference
[RegulationReference:9641575] Negative gene expression regulation by 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]' E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
[RegulationReference:9642011] Negative gene expression regulation by 'DREAM complex:E2F1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate
2011-09-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1538129] MacPherson, D, 2011-08-25
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8964513
summation
[Summation:8964512] Transcription of the E2F1 gene is directly inhibited by the ...
Referrals
(hasEvent)
[Pathway:R-HSA-1362300] Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex
(inferredTo)
[BlackBoxEvent:R-MMU-8979012] E2f1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1
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