Reactome | RBL1 gene expression is repressed by the DREAM complex

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RBL1 gene expression is repressed by the DREAM complex Show undefined attributes

authored	[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8964522] Orlic-Milacic, Marija, 2017-02-17
dbId	8964525
displayName	RBL1 gene expression is repressed by the DREAM complex
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
eventOf	[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
followingEvent	[Reaction:R-HSA-1363314] p107 (RBL1) binds CyclinE/A:CDK2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8964489] RBL1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RBL1 gene expression is repressed by the DREAM complex
output	[EntityWithAccessionedSequence:R-HSA-389104] RBL1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8964492] DREAM complex binds the RBL1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-8964523] Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641974] Negative gene expression regulation by 'DREAM complex:RBL1 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1538129] MacPherson, D, 2011-08-25
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8964525
summation	[Summation:8964524] The DREAM complex directly represses transcription of the RB...

Referrals

(precedingEvent)	[Reaction:R-HSA-1363314] p107 (RBL1) binds CyclinE/A:CDK2
(hasEvent)	[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex

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