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Entries
p130 (RBL2) associates with MuvB to form DREAM complex
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authored
[InstanceEdit:1363332] Orlic-Milacic, Marija, 2011-06-14
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1362263] Orlic-Milacic, Marija, 2011-06-07
dbId
1362261
displayName
p130 (RBL2) associates with MuvB to form DREAM complex
eventOf
[Pathway:R-HSA-1538133] G0 and Early G1 - Homo sapiens
followingEvent
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
[Reaction:R-HSA-8964465] DREAM complex binds the PCNA gene promoter - Homo sapiens
[Reaction:R-HSA-8964482] DREAM complex binds the E2F1 gene promoter - Homo sapiens
[Reaction:R-HSA-8964492] DREAM complex binds the RBL1 gene promoter - Homo sapiens
[Reaction:R-HSA-8964475] DREAM complex binds the TOP2A gene promoter - Homo sapiens
[Reaction:R-HSA-8964498] DREAM complex binds the CDC6 gene promoter - Homo sapiens
[Reaction:R-HSA-8964471] DREAM complex binds the CDC25A gene promoter - Homo sapiens
input
[Complex:R-HSA-1362259] p-MuvB complex [nucleoplasm]
[Complex:R-HSA-1226089] RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
[LiteratureReference:1362262] DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
modified
[InstanceEdit:10752251] Wright, Adam, 2022-11-19
name
p130 (RBL2) associates with MuvB to form DREAM complex
orthologousEvent
[Reaction:R-CEL-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Caenorhabditis elegans
[Reaction:R-DME-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Drosophila melanogaster
[Reaction:R-GGA-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Gallus gallus
[Reaction:R-XTR-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Xenopus tropicalis
[Reaction:R-DRE-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Danio rerio
[Reaction:R-SSC-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Sus scrofa
[Reaction:R-BTA-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Bos taurus
[Reaction:R-CFA-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Canis familiaris
[Reaction:R-RNO-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Rattus norvegicus
[Reaction:R-MMU-1362261] p130 (RBL2) associates with MuvB to form DREAM complex - Mus musculus
output
[Complex:R-HSA-1362264] DREAM complex [nucleoplasm]
precedingEvent
[Reaction:R-HSA-1362270] Phosphorylation of LIN52 component of MuvB by DYRK1A - Homo sapiens
releaseDate
2011-09-20
reviewed
[InstanceEdit:1538129] MacPherson, D, 2011-08-25
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1362261
summation
[Summation:1362257] In G0 and early G1, p130 (RBL2) bound to E2F4 or E2F5 and DP...
Referrals
(precedingEvent)
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex
[Reaction:R-HSA-8964465] DREAM complex binds the PCNA gene promoter
[Reaction:R-HSA-8964482] DREAM complex binds the E2F1 gene promoter
[Reaction:R-HSA-8964492] DREAM complex binds the RBL1 gene promoter
[Reaction:R-HSA-8964475] DREAM complex binds the TOP2A gene promoter
[Reaction:R-HSA-8964498] DREAM complex binds the CDC6 gene promoter
[Reaction:R-HSA-8964471] DREAM complex binds the CDC25A gene promoter
(hasEvent)
[Pathway:R-HSA-1538133] G0 and Early G1
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