Reactome | Nuclear signaling by ERBB4

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Nuclear signaling by ERBB4 Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
created	[InstanceEdit:1251989] Orlic-Milacic, Marija, 2011-04-26
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175
dbId	1251985
displayName	Nuclear signaling by ERBB4
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1236394] Signaling by ERBB4 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1251992] Cleavage of P-ERBB4jmA isoforms by ADAM17 - Homo sapiens [Reaction:R-HSA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Homo sapiens [BlackBoxEvent:R-HSA-1252013] Translocation of ERBB4s80 to the nucleus - Homo sapiens [Reaction:R-HSA-1253325] ERBB4s80 binds TAB2:NCOR1 complex - Homo sapiens [BlackBoxEvent:R-HSA-1253319] ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8954185] ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter - Homo sapiens [Reaction:R-HSA-8954182] ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1253321] GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1 - Homo sapiens [BlackBoxEvent:R-HSA-8954179] S100B gene expression is inhibited by ERBB4:TAB2:NCOR1 - Homo sapiens [Reaction:R-HSA-1253343] WWOX binds ERBB4s80 - Homo sapiens [Reaction:R-HSA-1254251] ERBB4s80 binds YAP1 - Homo sapiens [BlackBoxEvent:R-HSA-1254248] Translocation of ERBB4s80:YAP1 complex to the nucleus - Homo sapiens [Reaction:R-HSA-1254291] ERBB4s80 binds STAT5A - Homo sapiens [BlackBoxEvent:R-HSA-1254285] ERBB4s80:STAT5A complex translocates to the nucleus - Homo sapiens [Reaction:R-HSA-8954224] ERBB4s80:STAT5A binds CSN2 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1254290] CSN2 gene expression is stimulated by ERBB4s80:STAT5A - Homo sapiens [Reaction:R-HSA-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 - Homo sapiens [Reaction:R-HSA-8954208] ERBB4s80:ESR1 binds PGR gene promoter - Homo sapiens [Reaction:R-HSA-8954207] ERBB4s80:ESR1 binds CXCL12 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-1254392] PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen - Homo sapiens [BlackBoxEvent:R-HSA-8954199] CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen - Homo sapiens [Reaction:R-HSA-9612672] ERBB4s80:ESR1 binds ERBB4 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9612671] ERBB4 gene expression is stimulated by ERBB4s80:ESR1 - Homo sapiens [BlackBoxEvent:R-HSA-1254376] Translocation of cytosolic ERBB4s80 to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-9612246] ERBB4s80 binds the APOE gene - Homo sapiens [BlackBoxEvent:R-HSA-9612243] APOE gene transcription is stimulated by ERBB4s80 - Homo sapiens [Reaction:R-HSA-9612255] ERBB4s80 binds ADAP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9612257] ADAP1 gene expression is inhibited by ERBB4s80 - Homo sapiens [Reaction:R-HSA-9612278] ERBB4s80 binds SPARC gene - Homo sapiens [BlackBoxEvent:R-HSA-9612277] SPARC gene transcription is stimulated by ERBB4s80 - Homo sapiens [Reaction:R-HSA-9612444] ERBB4s80 binds STMN1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9612445] STMN1 gene expression is stimulated by ERBB4s80 - Homo sapiens [Reaction:R-HSA-9612440] ERBB4s80 binds the MXD4 gene - Homo sapiens [BlackBoxEvent:R-HSA-9612448] MXD4 gene expression is stimulated by ERBB4s80 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:1253338] WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function [LiteratureReference:1251998] Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment [LiteratureReference:1252006] Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 [LiteratureReference:9612232] Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src [LiteratureReference:1254249] WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus [LiteratureReference:1254297] Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation [LiteratureReference:1254404] The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells [LiteratureReference:1252005] gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase [LiteratureReference:1254250] Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level [LiteratureReference:1253316] Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain [LiteratureReference:1254286] The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone [LiteratureReference:1254407] Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Nuclear signaling by ERBB4
orthologousEvent	[Pathway:R-CFA-1251985] Nuclear signaling by ERBB4 - Canis familiaris [Pathway:R-CEL-1251985] Nuclear signaling by ERBB4 - Caenorhabditis elegans [Pathway:R-DME-1251985] Nuclear signaling by ERBB4 - Drosophila melanogaster [Pathway:R-GGA-1251985] Nuclear signaling by ERBB4 - Gallus gallus [Pathway:R-XTR-1251985] Nuclear signaling by ERBB4 - Xenopus tropicalis [Pathway:R-DRE-1251985] Nuclear signaling by ERBB4 - Danio rerio [Pathway:R-SSC-1251985] Nuclear signaling by ERBB4 - Sus scrofa [Pathway:R-BTA-1251985] Nuclear signaling by ERBB4 - Bos taurus [Pathway:R-RNO-1251985] Nuclear signaling by ERBB4 - Rattus norvegicus [Pathway:R-MMU-1251985] Nuclear signaling by ERBB4 - Mus musculus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
revised	[InstanceEdit:9638819] Stern, David F, 2019-02-21 [InstanceEdit:9612642] Orlic-Milacic, Marija, 2018-06-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1251985
summation	[Summation:1978808] Besides signaling as a transmembrane receptor, ligand activa...
updateTrackers	[UpdateTracker:9779353] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v65:[updateContainedRLE] [UpdateTracker:9777744] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v69:[addHasEvent] [UpdateTracker:9782358] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v59:[removeHasEvent] [UpdateTracker:9787877] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v44:[updateContainedRLE] [UpdateTracker:9779071] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v66:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9781910] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9788867] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v40:[addHasEvent, updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1236394] Signaling by ERBB4

(updatedInstance)

[UpdateTracker:9779353] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v65:[updateContainedRLE]
[UpdateTracker:9777744] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v69:[addHasEvent]
[UpdateTracker:9782358] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v59:[removeHasEvent]
[UpdateTracker:9787877] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v44:[updateContainedRLE]
[UpdateTracker:9779071] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v66:[addLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9781910] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9788867] Update Tracker - [Pathway:1251985] Nuclear signaling by ERBB4 - v40:[addHasEvent, updateContainedRLE]

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