Reactome | Nuclear signaling by ERBB4

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Nuclear signaling by ERBB4 Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649422
displayName	Nuclear signaling by ERBB4
eventOf	[Pathway:R-DRE-1236394] Signaling by ERBB4 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Danio rerio [BlackBoxEvent:R-DRE-1252013] Translocation of ERBB4s80 to the nucleus - Danio rerio [Reaction:R-DRE-1253343] WWOX binds ERBB4s80 - Danio rerio [Reaction:R-DRE-1254251] ERBB4s80 binds YAP1 - Danio rerio [BlackBoxEvent:R-DRE-1254248] Translocation of ERBB4s80:YAP1 complex to the nucleus - Danio rerio [Reaction:R-DRE-1254291] ERBB4s80 binds STAT5A - Danio rerio [BlackBoxEvent:R-DRE-1254285] ERBB4s80:STAT5A complex translocates to the nucleus - Danio rerio [Reaction:R-DRE-1254386] ERBB4s80 forms a complex with estrogen receptor ESR1 - Danio rerio [BlackBoxEvent:R-DRE-1254376] Translocation of cytosolic ERBB4s80 to mitochondrial matrix - Danio rerio
inferredFrom	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Nuclear signaling by ERBB4
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-1251985
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1236394] Signaling by ERBB4
(inferredTo)	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4

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