Reactome | Cleavage of P-ERBB4jmA isoforms by ADAM17

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Cleavage of P-ERBB4jmA isoforms by ADAM17 Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1251983] metalloendopeptidase activity of ADAM17 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1251989] Orlic-Milacic, Marija, 2011-04-26
dbId	1251992
displayName	Cleavage of P-ERBB4jmA isoforms by ADAM17
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4 - Homo sapiens
followingEvent	[Reaction:R-HSA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Homo sapiens
inferredFrom	[Reaction:R-NUL-1251988] Cleavage of P-ERBB4jmA isoforms by Adam17 - Homo sapiens
input	[DefinedSet:R-HSA-1843077] p-ERBB4 JM-A homodimers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of P-ERBB4jmA isoforms by ADAM17
output	[DefinedSet:R-HSA-1251970] ERBB4_ECD [extracellular region] [DefinedSet:R-HSA-1251960] ERBB4m80 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1250315] Trans-autophosphorylation of ERBB4 homodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1251992
summation	[Summation:1251993] Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoform...
updateTrackers	[UpdateTracker:9779456] Update Tracker - [Reaction:1251992] Cleavage of P-ERBB4jmA isoforms by ADAM17 - v65:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9779456] Update Tracker - [Reaction:1251992] Cleavage of P-ERBB4jmA isoforms by ADAM17 - v65:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4
(precedingEvent)	[Reaction:R-HSA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex
(inferredTo)	[Reaction:R-NUL-1251988] Cleavage of P-ERBB4jmA isoforms by Adam17

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