Reactome | Cleavage of ERBB4m80 by gamma-scretase complex

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Cleavage of ERBB4m80 by gamma-scretase complex Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:194541] endopeptidase activity of gamma-secretase complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1251989] Orlic-Milacic, Marija, 2011-04-26
dbId	1251997
displayName	Cleavage of ERBB4m80 by gamma-scretase complex
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4 - Homo sapiens
followingEvent	[Reaction:R-HSA-1253325] ERBB4s80 binds TAB2:NCOR1 complex - Homo sapiens [Reaction:R-HSA-1253343] WWOX binds ERBB4s80 - Homo sapiens [BlackBoxEvent:R-HSA-1254376] Translocation of cytosolic ERBB4s80 to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-1254251] ERBB4s80 binds YAP1 - Homo sapiens [Reaction:R-HSA-1254291] ERBB4s80 binds STAT5A - Homo sapiens [BlackBoxEvent:R-HSA-1252013] Translocation of ERBB4s80 to the nucleus - Homo sapiens
input	[DefinedSet:R-HSA-1251960] ERBB4m80 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1252005] gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Cleavage of ERBB4m80 by gamma-scretase complex
orthologousEvent	[Reaction:R-CFA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Canis familiaris [Reaction:R-CEL-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Caenorhabditis elegans [Reaction:R-DME-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Drosophila melanogaster [Reaction:R-GGA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Gallus gallus [Reaction:R-XTR-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Xenopus tropicalis [Reaction:R-DRE-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Danio rerio [Reaction:R-SSC-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Sus scrofa [Reaction:R-BTA-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Bos taurus [Reaction:R-RNO-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Rattus norvegicus [Reaction:R-MMU-1251997] Cleavage of ERBB4m80 by gamma-scretase complex - Mus musculus
output	[DefinedSet:R-HSA-1251980] ERBB4s80 [cytosol]
precedingEvent	[Reaction:R-HSA-1251992] Cleavage of P-ERBB4jmA isoforms by ADAM17 - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1251997
summation	[Summation:1251974] After ERBB4 is cleaved by ADAM17, gamma-secretase complex pe...
updateTrackers	[UpdateTracker:9779536] Update Tracker - [Reaction:1251997] Cleavage of ERBB4m80 by gamma-scretase complex - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779536] Update Tracker - [Reaction:1251997] Cleavage of ERBB4m80 by gamma-scretase complex - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4
(precedingEvent)	[Reaction:R-HSA-1253325] ERBB4s80 binds TAB2:NCOR1 complex [Reaction:R-HSA-1253343] WWOX binds ERBB4s80 [BlackBoxEvent:R-HSA-1254376] Translocation of cytosolic ERBB4s80 to mitochondrial matrix [Reaction:R-HSA-1254251] ERBB4s80 binds YAP1 [Reaction:R-HSA-1254291] ERBB4s80 binds STAT5A [BlackBoxEvent:R-HSA-1252013] Translocation of ERBB4s80 to the nucleus

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