Reactome | CSN2 gene expression is stimulated by ERBB4s80:STAT5A

Schema > BlackBoxEvent > Entries

CSN2 gene expression is stimulated by ERBB4s80:STAT5A Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1254294] Orlic-Milacic, Marija, 2011-04-28
dbId	1254290
displayName	CSN2 gene expression is stimulated by ERBB4s80:STAT5A
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8954222] CSN2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1254286] The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone [LiteratureReference:1254297] Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation [LiteratureReference:2029515] ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSN2 gene expression is stimulated by ERBB4s80:STAT5A
output	[EntityWithAccessionedSequence:R-HSA-1254293] CSN2 [extracellular region]
precedingEvent	[Reaction:R-HSA-8954224] ERBB4s80:STAT5A binds CSN2 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1254289] Positive gene expression regulation by 'ERBB4s80:p-Y694-STAT5A:CSN2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641564] Positive gene expression regulation by 'ERBB4s80:p-Y694-STAT5A:CSN2 gene [nucleoplasm]' The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
revised	[InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1254290
summation	[Summation:1254282] ERBB4s80:STAT5A complex binds to and stimulates transcriptio...

Referrals

(hasEvent)

[Pathway:R-HSA-1251985] Nuclear signaling by ERBB4