Reactome | myristoylated nef [cytosol]

Schema > EntityWithAccessionedSequence > Entries

myristoylated nef [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-182256] Nef:class I MHC complex [Golgi membrane] - Homo sapiens [Complex:R-HSA-182230] Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] - Homo sapiens [Complex:R-HSA-182254] Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] - Homo sapiens [Complex:R-HSA-3149451] Assembling HIV virion [plasma membrane] - Homo sapiens [Complex:R-HSA-173664] Viral core surrounded by Matrix layer [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-167630] Formation of Nef CD28 cytoplasmic tail complex - Homo sapiens [Reaction:R-HSA-200908] Nef Binds and activates the Src-family tyrosine kinase Fyn - Homo sapiens [Reaction:R-HSA-164943] Nef mediated activation of the T-cell receptor - Homo sapiens [Reaction:R-HSA-200954] Nef Binds and activates the Src-family tyrosine kinase Lck - Homo sapiens [Reaction:R-HSA-200858] Nef Binds and activates the Src-family tyrosine kinase Hck - Homo sapiens [Reaction:R-HSA-182243] Formation of MHC I:Nef Complex - Homo sapiens [Reaction:R-HSA-167566] Nef mediated disruption of CD4:Lck Complex - Homo sapiens [Reaction:R-HSA-200879] Formation of a Nef:ARF1:CD4 complex - Homo sapiens [Reaction:R-HSA-200952] Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction - Homo sapiens [Reaction:R-HSA-3149454] Packaging of HIV virion on the host cell plasma membrane - Homo sapiens
created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
dbId	167605
displayName	myristoylated nef [cytosol]
goCellularComponent	[Compartment:436407] host cell cytosol
hasModifiedResidue	[ModifiedResidue:167595] N-myristoylglycine at 1
inDisease	false
maxDepth	1
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	myristoylated nef
producedByEvent	[Reaction:R-HSA-162914] Myristoylation of Nef - Homo sapiens [BlackBoxEvent:R-HSA-182171] Degradation of CD8 - Homo sapiens [BlackBoxEvent:R-HSA-167601] Degradation of CD4 - Homo sapiens [BlackBoxEvent:R-HSA-182263] Degradation of MHC I Complex - Homo sapiens [Depolymerisation:R-HSA-173642] Disintegration of matrix layer - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P04601] UniProt:P04601 nef
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:164493] Human immunodeficiency virus 1
stId	R-HIV-167605
updateTrackers	[UpdateTracker:9894372] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v57:[modifyName] [UpdateTracker:9878170] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v44:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9894372] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v57:[modifyName] [UpdateTracker:9878170] Update Tracker - [EntityWithAccessionedSequence:167605] myristoylated nef [cytosol] - v44:[modifyName]
(hasComponent)	[Complex:R-HSA-3149451] Assembling HIV virion [plasma membrane] [Complex:R-HSA-173664] Viral core surrounded by Matrix layer [cytosol] [Complex:R-HSA-182254] Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] [Complex:R-HSA-182373] Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] [Complex:R-HSA-182256] Nef:class I MHC complex [Golgi membrane] [Complex:R-HSA-167631] CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol] [Complex:R-HSA-167629] Nef:CD28 Complex [plasma membrane] [Complex:R-HSA-182230] Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] [Complex:R-HSA-182194] CD8:Nef Complex [plasma membrane] [Complex:R-HSA-200867] Arf1:Nef:endosomal CD4 [early endosome membrane] [Complex:R-HSA-167554] Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane] [Complex:R-HSA-167596] CD4:Nef Complex [plasma membrane] [Complex:R-HSA-200911] Fyn:Nef Complex [cytosol] [Complex:R-HSA-167576] Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane] [Complex:R-HSA-200937] DOCK2:ELMO1:RAC1:Nef Complex [cytosol] [Complex:R-HSA-200922] Lck:Nef [cytosol] [Complex:R-HSA-200872] Hck-1:Nef [cytosol]
(input)	[Reaction:R-HSA-3149454] Packaging of HIV virion on the host cell plasma membrane [Reaction:R-HSA-182243] Formation of MHC I:Nef Complex [Reaction:R-HSA-167630] Formation of Nef CD28 cytoplasmic tail complex [Reaction:R-HSA-200879] Formation of a Nef:ARF1:CD4 complex [Reaction:R-HSA-167566] Nef mediated disruption of CD4:Lck Complex [Reaction:R-HSA-200908] Nef Binds and activates the Src-family tyrosine kinase Fyn [Reaction:R-HSA-164943] Nef mediated activation of the T-cell receptor [Reaction:R-HSA-200952] Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction [Reaction:R-HSA-200954] Nef Binds and activates the Src-family tyrosine kinase Lck [Reaction:R-HSA-200858] Nef Binds and activates the Src-family tyrosine kinase Hck
(output)	[Reaction:R-HSA-162914] Myristoylation of Nef [Depolymerisation:R-HSA-173642] Disintegration of matrix layer [BlackBoxEvent:R-HSA-182263] Degradation of MHC I Complex [BlackBoxEvent:R-HSA-182171] Degradation of CD8 [BlackBoxEvent:R-HSA-167601] Degradation of CD4

© 2026 Reactome

Cite Us!