Reactome | Nef mediated disruption of CD4:Lck Complex

Schema > Reaction > Entries

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
dbId	167566
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef mediated disruption of CD4:Lck Complex
eventOf	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens
input	[Complex:R-HSA-167529] CD4:Lck Complex [plasma membrane] [EntityWithAccessionedSequence:R-HIV-167605] myristoylated nef [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182238] Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nef mediated disruption of CD4:Lck Complex
output	[Complex:R-HSA-167596] CD4:Nef Complex [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167609] LCK [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167566
summation	[Summation:201386] Nef disrupts the CD4 Lck complex

(hasEvent)	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation
(precedingEvent)	[Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex

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