Reactome | Nef Binds and activates the Src-family tyrosine kinase Lck

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Nef Binds and activates the Src-family tyrosine kinase Lck Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:200953] Gillespie, ME, 2007-07-26 04:51:49
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	200954
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef Binds and activates the Src-family tyrosine kinase Lck
eventOf	[Pathway:R-HSA-164944] Nef and signal transduction - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-167609] LCK [cytosol] [EntityWithAccessionedSequence:R-HIV-167605] myristoylated nef [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:200833] Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4 [LiteratureReference:200936] The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nef Binds and activates the Src-family tyrosine kinase Lck
output	[Complex:R-HSA-200922] Lck:Nef [cytosol]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200954
summation	[Summation:200933] The Nef protein of the primate lentiviruses, including human...
updateTrackers	[UpdateTracker:9787564] Update Tracker - [Reaction:200954] Nef Binds and activates the Src-family tyrosine kinase Lck - v44:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9787564] Update Tracker - [Reaction:200954] Nef Binds and activates the Src-family tyrosine kinase Lck - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-164944] Nef and signal transduction

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