Reactome | Formation of a Nef:ARF1:CD4 complex

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Formation of a Nef:ARF1:CD4 complex Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	binding
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:200838] Gillespie, ME, 2007-07-25 19:41:34
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	200879
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Formation of a Nef:ARF1:CD4 complex
eventOf	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-167601] Degradation of CD4 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-200826] ARF1 [cytosol] [EntityWithAccessionedSequence:R-HSA-167542] CD4 [plasma membrane] [EntityWithAccessionedSequence:R-HIV-167605] myristoylated nef [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:200844] ARF1 regulates Nef-induced CD4 degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of a Nef:ARF1:CD4 complex
output	[Complex:R-HSA-200867] Arf1:Nef:endosomal CD4 [early endosome membrane]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200879
summation	[Summation:200857] The HIV Nef protein downregulates CD4 through sequential con...
updateTrackers	[UpdateTracker:9787887] Update Tracker - [Reaction:200879] Formation of a Nef:ARF1:CD4 complex - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787887] Update Tracker - [Reaction:200879] Formation of a Nef:ARF1:CD4 complex - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation
(precedingEvent)	[BlackBoxEvent:R-HSA-167601] Degradation of CD4

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