Reactome | Nef mediated activation of the T-cell receptor

Schema > Reaction > Entries

Nef mediated activation of the T-cell receptor Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:164942] Gillespie, ME, 2005-07-22 21:04:05
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164943
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef mediated activation of the T-cell receptor
eventOf	[Pathway:R-HSA-164944] Nef and signal transduction - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
input	[EntityWithAccessionedSequence:R-HSA-198166] CD247-1 [plasma membrane] [OtherEntity:R-ALL-167540] Lipid Raft [cytosol] [EntityWithAccessionedSequence:R-HIV-167605] myristoylated nef [cytosol] [EntityWithAccessionedSequence:R-HSA-164946] PAK2(1-524) [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182142] Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex [LiteratureReference:182200] The Nef protein of HIV-1 associates with rafts and primes T cells for activation [LiteratureReference:200923] Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation [LiteratureReference:200926] CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable [LiteratureReference:200924] Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX [LiteratureReference:200959] Identification of the Nef-associated kinase as p21-activated kinase 2 [LiteratureReference:200940] Lentivirus Nef specifically activates Pak2
maxDepth	1
modified	[InstanceEdit:9953542] Gillespie, Marc E, 2025-06-03
name	Nef mediated activation of the T-cell receptor
output	[Complex:R-HSA-167576] Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-09-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-164943
summation	[Summation:182201] Nef drives the formation of lipid raft complexes.
updateTrackers	[UpdateTracker:9787549] Update Tracker - [Reaction:164943] Nef mediated activation of the T-cell receptor - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9787549] Update Tracker - [Reaction:164943] Nef mediated activation of the T-cell receptor - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-164944] Nef and signal transduction