Reactome | cGMP [cytosol]

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cGMP [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-4551456] PRKG homodimer:cGMP [cytosol] - Homo sapiens [Complex:R-HSA-4551456] PRKG homodimer:cGMP [cytosol] - Homo sapiens [Complex:R-HSA-4551456] PRKG homodimer:cGMP [cytosol] - Homo sapiens [Complex:R-HSA-4551456] PRKG homodimer:cGMP [cytosol] - Homo sapiens [Complex:R-DME-74011] cGMP:CNG channel [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DDI-74059] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-GGA-74059] PDE6 hydrolyses cGMP to GMP - Gallus gallus [Reaction:R-XTR-74059] PDE6 hydrolyses cGMP to GMP - Xenopus tropicalis [Reaction:R-DRE-74059] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-SSC-74059] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-BTA-74059] PDE6 hydrolyses cGMP to GMP - Bos taurus [Reaction:R-CFA-74059] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-RNO-74059] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-MMU-74059] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling - Homo sapiens [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling - Homo sapiens [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling - Homo sapiens [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling - Homo sapiens [Reaction:R-HSA-418456] cGMP is degraded by PDEs - Homo sapiens [Reaction:R-MMU-418456] cGMP is degraded by PDEs - Mus musculus [Reaction:R-RNO-418456] cGMP is degraded by PDEs - Rattus norvegicus [Reaction:R-CFA-418456] cGMP is degraded by PDEs - Canis familiaris [Reaction:R-BTA-418456] cGMP is degraded by PDEs - Bos taurus [Reaction:R-SSC-418456] cGMP is degraded by PDEs - Sus scrofa [Reaction:R-DRE-418456] cGMP is degraded by PDEs - Danio rerio [Reaction:R-XTR-418456] cGMP is degraded by PDEs - Xenopus tropicalis [Reaction:R-GGA-418456] cGMP is degraded by PDEs - Gallus gallus [Reaction:R-DME-418456] cGMP is degraded by PDEs - Drosophila melanogaster [Reaction:R-CEL-418456] cGMP is degraded by PDEs - Caenorhabditis elegans [Reaction:R-DDI-418456] cGMP is degraded by PDEs - Dictyostelium discoideum [Reaction:R-PFA-418456] cGMP is degraded by PDEs - Plasmodium falciparum [Reaction:R-CEL-74031] cGMP binds CNG channel to form cGMP:CNG channel - Caenorhabditis elegans [Reaction:R-DME-74031] cGMP binds CNG channel to form cGMP:CNG channel - Drosophila melanogaster [Reaction:R-GGA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Gallus gallus [Reaction:R-SSC-74031] cGMP binds CNG channel to form cGMP:CNG channel - Sus scrofa [Reaction:R-BTA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Bos taurus [Reaction:R-CFA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Canis familiaris [Reaction:R-RNO-74031] cGMP binds CNG channel to form cGMP:CNG channel - Rattus norvegicus [Reaction:R-HSA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Homo sapiens [Reaction:R-HSA-4086392] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-MMU-4086392] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-RNO-4086392] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-CFA-4086392] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-BTA-4086392] PDE6 hydrolyses cGMP to GMP - Bos taurus [Reaction:R-SSC-4086392] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-DRE-4086392] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-XTR-4086392] PDE6 hydrolyses cGMP to GMP - Xenopus tropicalis [Reaction:R-GGA-4086392] PDE6 hydrolyses cGMP to GMP - Gallus gallus [Reaction:R-DDI-4086392] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-MMU-4551446] Prkg is activated upon cGMP binding - Mus musculus [Reaction:R-MMU-4551446] Prkg is activated upon cGMP binding - Mus musculus [Reaction:R-MMU-4551446] Prkg is activated upon cGMP binding - Mus musculus [Reaction:R-MMU-4551446] Prkg is activated upon cGMP binding - Mus musculus [Reaction:R-HSA-418451] cGMP stimulates Protein Kinase G - Homo sapiens [Reaction:R-HSA-418451] cGMP stimulates Protein Kinase G - Homo sapiens [Reaction:R-HAM-427308] cGMP stimulates Protein Kinase G - Homarus americanus [Reaction:R-HAM-427308] cGMP stimulates Protein Kinase G - Homarus americanus [Reaction:R-MMU-74031] cGMP binds CNG channel to form cGMP:CNG channel - Mus musculus
crossReference	[DatabaseIdentifier:30992] COMPOUND:C00942
dbId	30991
displayName	cGMP [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-561078] OAT1,2,3 substrates [cytosol]
modified	[InstanceEdit:9971695] Stephan, Ralf, 2025-11-10
name	cGMP Guanosine 3',5'-cyclic monophosphate 3',5'-cyclic GMP Guanosine 3',5'-cyclic phosphate Cyclic GMP
negativelyRegulates	[NegativeRegulation:9620126] Negative regulation by 'cGMP [cytosol]'
producedByEvent	[Reaction:R-DDI-74885] GUCYs converts GTP to cGMP - Dictyostelium discoideum [Reaction:R-DME-74885] GUCYs converts GTP to cGMP - Drosophila melanogaster [Reaction:R-XTR-74885] GUCYs converts GTP to cGMP - Xenopus tropicalis [Reaction:R-DRE-74885] GUCYs converts GTP to cGMP - Danio rerio [Reaction:R-SSC-74885] GUCYs converts GTP to cGMP - Sus scrofa [Reaction:R-BTA-74885] GUCYs converts GTP to cGMP - Bos taurus [Reaction:R-CFA-74885] GUCYs converts GTP to cGMP - Canis familiaris [Reaction:R-RNO-74885] GUCYs converts GTP to cGMP - Rattus norvegicus [Reaction:R-HSA-392152] Soluble guanylate cyclase converts GTP to cGMP - Homo sapiens [Reaction:R-RNO-427288] Soluble guanylate cyclase converts GTP to cGMP - Rattus norvegicus [Reaction:R-MMU-74885] GUCYs converts GTP to cGMP - Mus musculus [Reaction:R-HSA-74885] GUCYs converts GTP to cGMP - Homo sapiens [Reaction:R-CEL-2514865] cGMP dissociates from CNG channels - Caenorhabditis elegans [Reaction:R-DME-2514865] cGMP dissociates from CNG channels - Drosophila melanogaster [Reaction:R-GGA-2514865] cGMP dissociates from CNG channels - Gallus gallus [Reaction:R-SSC-2514865] cGMP dissociates from CNG channels - Sus scrofa [Reaction:R-BTA-2514865] cGMP dissociates from CNG channels - Bos taurus [Reaction:R-CFA-2514865] cGMP dissociates from CNG channels - Canis familiaris [Reaction:R-RNO-2514865] cGMP dissociates from CNG channels - Rattus norvegicus [Reaction:R-HSA-2514865] cGMP dissociates from CNG channels - Homo sapiens [Reaction:R-MMU-2514865] cGMP dissociates from CNG channels - Mus musculus
referenceEntity	[ReferenceMolecule:chebi:57746] 3',5'-cyclic GMP(1-) [ChEBI:57746]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-30991
updateTrackers	[UpdateTracker:9972775] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v95:[add_removeReferenceEntity] [UpdateTracker:9890842] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v52:[modifyName] [UpdateTracker:9873384] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v43:[addName]

Referrals

(hasComponent)	[Complex:R-DME-74011] cGMP:CNG channel [plasma membrane] [Complex:R-GGA-74011] cGMP:CNG channel [plasma membrane] [Complex:R-CFA-74011] cGMP:CNG channel [plasma membrane] [Complex:R-BTA-74011] cGMP:CNG channel [plasma membrane] [Complex:R-SSC-74011] cGMP:CNG channel [plasma membrane] [Complex:R-RNO-74011] cGMP:CNG channel [plasma membrane] [Complex:R-CEL-74011] cGMP:CNG channel [plasma membrane] [Complex:R-HSA-74011] cGMP:CNG channel [plasma membrane] [Complex:R-RNO-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-HSA-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-BTA-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-CFA-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-CEL-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-MMU-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-SSC-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-DME-9653485] PRKG2 dimer:cGMP [cytosol] [Complex:R-HSA-4551456] PRKG homodimer:cGMP [cytosol] [Complex:R-MMU-4551452] Prkg homodimer:cGMP [cytosol] [Complex:R-HSA-418378] Activated cGMP-dependent protein kinase (PKGs) [cytosol] [Complex:R-HAM-427305] Activated cGMP-dependent protein kinase (PKG) [cytosol] [Complex:R-MMU-74011] cGMP:CNG channel [plasma membrane]
(input)	[Reaction:R-DDI-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-GGA-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-XTR-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-DRE-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-SSC-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-BTA-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-CFA-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-RNO-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-MMU-74059] PDE6 hydrolyses cGMP to GMP [Reaction:R-CEL-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-DME-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-GGA-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-SSC-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-BTA-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-CFA-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-RNO-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-HSA-74031] cGMP binds CNG channel to form cGMP:CNG channel [Reaction:R-HSA-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-MMU-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-RNO-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-CFA-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-BTA-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-SSC-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-DRE-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-XTR-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-GGA-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-DDI-4086392] PDE6 hydrolyses cGMP to GMP [Reaction:R-HSA-4551453] PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling [Reaction:R-MMU-4551446] Prkg is activated upon cGMP binding [Reaction:R-HSA-418451] cGMP stimulates Protein Kinase G [Reaction:R-HAM-427308] cGMP stimulates Protein Kinase G [Reaction:R-HSA-418456] cGMP is degraded by PDEs [Reaction:R-MMU-418456] cGMP is degraded by PDEs [Reaction:R-RNO-418456] cGMP is degraded by PDEs [Reaction:R-CFA-418456] cGMP is degraded by PDEs [Reaction:R-BTA-418456] cGMP is degraded by PDEs [Reaction:R-SSC-418456] cGMP is degraded by PDEs [Reaction:R-DRE-418456] cGMP is degraded by PDEs [Reaction:R-XTR-418456] cGMP is degraded by PDEs [Reaction:R-GGA-418456] cGMP is degraded by PDEs [Reaction:R-DME-418456] cGMP is degraded by PDEs [Reaction:R-CEL-418456] cGMP is degraded by PDEs [Reaction:R-DDI-418456] cGMP is degraded by PDEs [Reaction:R-PFA-418456] cGMP is degraded by PDEs [Reaction:R-MMU-74031] cGMP binds CNG channel to form cGMP:CNG channel
(output)	[Reaction:R-CEL-2514865] cGMP dissociates from CNG channels [Reaction:R-DME-2514865] cGMP dissociates from CNG channels [Reaction:R-GGA-2514865] cGMP dissociates from CNG channels [Reaction:R-SSC-2514865] cGMP dissociates from CNG channels [Reaction:R-BTA-2514865] cGMP dissociates from CNG channels [Reaction:R-CFA-2514865] cGMP dissociates from CNG channels [Reaction:R-RNO-2514865] cGMP dissociates from CNG channels [Reaction:R-HSA-2514865] cGMP dissociates from CNG channels [Reaction:R-MMU-2514865] cGMP dissociates from CNG channels [Reaction:R-DDI-74885] GUCYs converts GTP to cGMP [Reaction:R-DME-74885] GUCYs converts GTP to cGMP [Reaction:R-XTR-74885] GUCYs converts GTP to cGMP [Reaction:R-DRE-74885] GUCYs converts GTP to cGMP [Reaction:R-SSC-74885] GUCYs converts GTP to cGMP [Reaction:R-BTA-74885] GUCYs converts GTP to cGMP [Reaction:R-CFA-74885] GUCYs converts GTP to cGMP [Reaction:R-RNO-74885] GUCYs converts GTP to cGMP [Reaction:R-HSA-392152] Soluble guanylate cyclase converts GTP to cGMP [Reaction:R-RNO-427288] Soluble guanylate cyclase converts GTP to cGMP [Reaction:R-MMU-74885] GUCYs converts GTP to cGMP [Reaction:R-HSA-74885] GUCYs converts GTP to cGMP
(hasMember)	[DefinedSet:R-ALL-561078] OAT1,2,3 substrates [cytosol]
(regulator)	[NegativeRegulation:9620126] Negative regulation by 'cGMP [cytosol]'
(updatedInstance)	[UpdateTracker:9972775] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v95:[add_removeReferenceEntity] [UpdateTracker:9890842] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v52:[modifyName] [UpdateTracker:9873384] Update Tracker - [SimpleEntity:30991] cGMP [cytosol] - v43:[addName]

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