Reactome | cGMP is degraded by PDEs

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cGMP is degraded by PDEs Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:418559] 3',5'-cyclic-GMP phosphodiesterase activity of cGMP phosphodiesterases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:418459] Jupe, S, 2009-04-22 15:45:31
crossReference	[DatabaseIdentifier:12667491] RHEA:16958
dbId	418456
displayName	cGMP is degraded by PDEs
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-418457] cGMP effects - Homo sapiens
input	[SimpleEntity:R-ALL-30991] cGMP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427866] Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	cGMP is degraded by PDEs
orthologousEvent	[Reaction:R-PFA-418456] cGMP is degraded by PDEs - Plasmodium falciparum [Reaction:R-DDI-418456] cGMP is degraded by PDEs - Dictyostelium discoideum [Reaction:R-CEL-418456] cGMP is degraded by PDEs - Caenorhabditis elegans [Reaction:R-DME-418456] cGMP is degraded by PDEs - Drosophila melanogaster [Reaction:R-GGA-418456] cGMP is degraded by PDEs - Gallus gallus [Reaction:R-XTR-418456] cGMP is degraded by PDEs - Xenopus tropicalis [Reaction:R-DRE-418456] cGMP is degraded by PDEs - Danio rerio [Reaction:R-SSC-418456] cGMP is degraded by PDEs - Sus scrofa [Reaction:R-BTA-418456] cGMP is degraded by PDEs - Bos taurus [Reaction:R-CFA-418456] cGMP is degraded by PDEs - Canis familiaris [Reaction:R-RNO-418456] cGMP is degraded by PDEs - Rattus norvegicus [Reaction:R-MMU-418456] cGMP is degraded by PDEs - Mus musculus
output	[SimpleEntity:R-ALL-113578] GMP [cytosol]
precedingEvent	[Reaction:R-HSA-392152] Soluble guanylate cyclase converts GTP to cGMP - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-418456
summation	[Summation:418566] Cyclic GMP phosphodiesterase are hydrolases selective for cA...
updateTrackers	[UpdateTracker:9782337] Update Tracker - [Reaction:418456] cGMP is degraded by PDEs - v59:[modifyText] [UpdateTracker:9789772] Update Tracker - [Reaction:418456] cGMP is degraded by PDEs - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782337] Update Tracker - [Reaction:418456] cGMP is degraded by PDEs - v59:[modifyText] [UpdateTracker:9789772] Update Tracker - [Reaction:418456] cGMP is degraded by PDEs - v37:[modifyText]
(hasEvent)	[Pathway:R-HSA-418457] cGMP effects