Reactome | GUCYs converts GTP to cGMP

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GUCYs converts GTP to cGMP Show undefined attributes

authored	[InstanceEdit:74470] Carleton, KL, 2003-07-22 11:02:31
catalystActivity	[CatalystActivity:74884] guanylate cyclase activity of GUCYs [photoreceptor disc membrane]
category	transition
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
crossReference	[DatabaseIdentifier:12668263] RHEA:13666
dbId	74885
displayName	GUCYs converts GTP to cGMP
edited	[InstanceEdit:2648981] Jassal, Bijay, 2012-11-22
eventOf	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:74892] Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. [LiteratureReference:2586756] Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily [LiteratureReference:2586746] The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1) [LiteratureReference:75335] Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. [LiteratureReference:74890] Molecular cloning of a retina-specific membrane guanylyl cyclase.
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GUCYs converts GTP to cGMP cGMP synthesis by guanylyl cyclase
orthologousEvent	[Reaction:R-MMU-74885] GUCYs converts GTP to cGMP - Mus musculus [Reaction:R-DDI-74885] GUCYs converts GTP to cGMP - Dictyostelium discoideum [Reaction:R-DME-74885] GUCYs converts GTP to cGMP - Drosophila melanogaster [Reaction:R-XTR-74885] GUCYs converts GTP to cGMP - Xenopus tropicalis [Reaction:R-DRE-74885] GUCYs converts GTP to cGMP - Danio rerio [Reaction:R-SSC-74885] GUCYs converts GTP to cGMP - Sus scrofa [Reaction:R-BTA-74885] GUCYs converts GTP to cGMP - Bos taurus [Reaction:R-CFA-74885] GUCYs converts GTP to cGMP - Canis familiaris [Reaction:R-RNO-74885] GUCYs converts GTP to cGMP - Rattus norvegicus
output	[SimpleEntity:R-ALL-30991] cGMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-2586745] Negative regulation by 'GUCA:Ca2+ [photoreceptor disc membrane]' [PositiveRegulation:R-HSA-9034480] Positive regulation by 'GUCA1B [cytosol]' [PositiveRegulation:R-HSA-9034482] Positive regulation by 'GUCA1A [cytosol]' [NegativeRegulation:R-HSA-9034483] Negative regulation by 'GCAP1:Ca2+ [cytosol]' [NegativeRegulation:R-HSA-9034486] Negative regulation by 'GCAP2:Ca2+ [cytosol]'
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74885
summation	[Summation:74889] The basal, "dark" levels of cGMP are restored as part of the...
updateTrackers	[UpdateTracker:9779971] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v64:[addRegulator] [UpdateTracker:9786811] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v48:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9779971] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v64:[addRegulator] [UpdateTracker:9786811] Update Tracker - [Reaction:74885] GUCYs converts GTP to cGMP - v48:[removeRegulator]
(hasEvent)	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade
(precedingEvent)	[Reaction:R-HSA-74031] cGMP binds CNG channel to form cGMP:CNG channel

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