Reactome | GUCYs converts GTP to cGMP

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GUCYs converts GTP to cGMP Show undefined attributes

catalystActivity	[CatalystActivity:10451851] guanylate cyclase activity of GUCYs [photoreceptor disc membrane]
category	transition
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10451875
displayName	GUCYs converts GTP to cGMP
eventOf	[Pathway:R-SSC-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-74031] cGMP binds CNG channel to form cGMP:CNG channel - Sus scrofa
inferredFrom	[Reaction:R-HSA-74885] GUCYs converts GTP to cGMP - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GUCYs converts GTP to cGMP cGMP synthesis by guanylyl cyclase
output	[SimpleEntity:R-ALL-30991] cGMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
regulatedBy	[NegativeRegulation:10451876] Negative regulation by 'GUCA:Ca2+ [photoreceptor disc membrane]' [PositiveRegulation:10451877] Positive regulation by 'GUCA1B [cytosol]' [PositiveRegulation:10451878] Positive regulation by 'GUCA1A [cytosol]' [NegativeRegulation:10451879] Negative regulation by 'GCAP1:Ca2+ [cytosol]' [NegativeRegulation:10451880] Negative regulation by 'GCAP2:Ca2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-74885
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2514859] Inactivation, recovery and regulation of the phototransduction cascade
(precedingEvent)	[Reaction:R-SSC-74031] cGMP binds CNG channel to form cGMP:CNG channel
(inferredTo)	[Reaction:R-HSA-74885] GUCYs converts GTP to cGMP