Reactome | PDE6 hydrolyses cGMP to GMP

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PDE6 hydrolyses cGMP to GMP Show undefined attributes

catalystActivity	[CatalystActivity:10108114] 3',5'-cyclic-GMP phosphodiesterase activity of GNAT1-GTP:PDE6 [photoreceptor disc membrane]
category	transition
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108116
displayName	PDE6 hydrolyses cGMP to GMP
eventOf	[Pathway:R-RNO-2485179] Activation of the phototransduction cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2514865] cGMP dissociates from CNG channels - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens
input	[SimpleEntity:R-ALL-30991] cGMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDE6 hydrolyses cGMP to GMP
output	[SimpleEntity:R-ALL-113578] GMP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74059
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2485179] Activation of the phototransduction cascade
(precedingEvent)	[Reaction:R-RNO-2514865] cGMP dissociates from CNG channels
(inferredTo)	[Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP

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