Reactome | Soluble guanylate cyclase converts GTP to cGMP

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Soluble guanylate cyclase converts GTP to cGMP Show undefined attributes

authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
catalystActivity	[CatalystActivity:392149] guanylate cyclase activity of Guanylate cyclase:NO [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:392151] Jupe, S, 2009-02-27 13:41:16
crossReference	[DatabaseIdentifier:11880400] Rhea:13666
dbId	392152
displayName	Soluble guanylate cyclase converts GTP to cGMP
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
eventOf	[Pathway:R-HSA-392154] Nitric oxide stimulates guanylate cyclase - Homo sapiens [Pathway:R-HSA-445355] Smooth Muscle Contraction - Homo sapiens
followingEvent	[Reaction:R-HSA-418456] cGMP is degraded by PDEs - Homo sapiens [Reaction:R-HSA-418451] cGMP stimulates Protein Kinase G - Homo sapiens
inferredFrom	[Reaction:R-RNO-427288] Soluble guanylate cyclase converts GTP to cGMP - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	Soluble guanylate cyclase converts GTP to cGMP
output	[SimpleEntity:R-ALL-30991] cGMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-392143] NO binds to Guanylate Cyclase - Homo sapiens
regulatedBy	[PositiveRegulation:9621125] Positive regulation by 'NO:sGC:sGC stimulators [cytosol]' [PositiveRegulation:9621122] Positive regulation by 'NO:sGC:cinaciguat [cytosol]' [PositiveRegulation:R-HSA-478867] Positive regulation by 'NO [cytosol]' [PositiveRegulation:9709370] Positive regulation by 'Guanylate cyclase:CO [cytosol]'
regulationReference	[RegulationReference:9709389] Positive regulation by 'Guanylate cyclase:CO [cytosol]' Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392152
summation	[Summation:418437] Soluble guanylate cyclase (sGC) is a heterodimeric hemoprote...

Referrals

(hasEvent)	[Pathway:R-HSA-445355] Smooth Muscle Contraction [Pathway:R-HSA-392154] Nitric oxide stimulates guanylate cyclase
(precedingEvent)	[Reaction:R-HSA-418456] cGMP is degraded by PDEs [Reaction:R-HSA-418451] cGMP stimulates Protein Kinase G
(inferredTo)	[Reaction:R-RNO-427288] Soluble guanylate cyclase converts GTP to cGMP