Reactome | PDE6 hydrolyses cGMP to GMP

Schema > Reaction > Entries

PDE6 hydrolyses cGMP to GMP Show undefined attributes

authored	[InstanceEdit:73925] Schmidt, EE, 2003-07-11 09:09:49
catalystActivity	[CatalystActivity:2514875] 3',5'-cyclic-GMP phosphodiesterase activity of GNAT1-GTP:PDE6 [photoreceptor disc membrane]
category	transition
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
crossReference	[DatabaseIdentifier:12667491] RHEA:16958
dbId	74059
displayName	PDE6 hydrolyses cGMP to GMP
edited	[InstanceEdit:2534149] Jassal, B, 2012-10-24
eventOf	[Pathway:R-HSA-2485179] Activation of the phototransduction cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-2514865] cGMP dissociates from CNG channels - Homo sapiens
input	[SimpleEntity:R-ALL-30991] cGMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2534118] Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3 [LiteratureReference:74440] Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina [LiteratureReference:74432] Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene [LiteratureReference:3262435] Light activation of phosphodiesterase activity in retinal rod outer segments [LiteratureReference:3262445] Light and dark active phosphodiesterase regulation in salamander rods [LiteratureReference:3262446] Regulation of cyclic GMP metabolism in toad photoreceptors. Definition of the metabolic events subserving photoexcited and attenuated states [LiteratureReference:3262436] Light-regulated guanosine 3',5'-monophosphate phosphodiesterase of bovine retina [LiteratureReference:3262478] Control of light-sensitive current in salamander rods [LiteratureReference:3262465] Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light [LiteratureReference:3262441] Molecular origin of continuous dark noise in rod photoreceptors [LiteratureReference:3262468] Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PDE6 hydrolyses cGMP to GMP
orthologousEvent	[Reaction:R-MMU-74059] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-DDI-74059] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-GGA-74059] PDE6 hydrolyses cGMP to GMP - Gallus gallus [Reaction:R-XTR-74059] PDE6 hydrolyses cGMP to GMP - Xenopus tropicalis [Reaction:R-DRE-74059] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-SSC-74059] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-BTA-74059] PDE6 hydrolyses cGMP to GMP - Bos taurus [Reaction:R-CFA-74059] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-RNO-74059] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus
output	[SimpleEntity:R-ALL-113578] GMP [cytosol]
precedingEvent	[Reaction:R-HSA-74065] GNAT1-GTP binds PDE6 and activates it - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74059
summation	[Summation:2514878] Phosphodiesterase 6 (PDE6, Pittler et al. 1990, Tuteja et al...
updateTrackers	[UpdateTracker:9786756] Update Tracker - [Reaction:74059] PDE6 hydrolyses cGMP to GMP - v48:[modifyText, removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786756] Update Tracker - [Reaction:74059] PDE6 hydrolyses cGMP to GMP - v48:[modifyText, removeRegulator]
(hasEvent)	[Pathway:R-HSA-2485179] Activation of the phototransduction cascade
(precedingEvent)	[Reaction:R-HSA-2514865] cGMP dissociates from CNG channels

Cite Us!