Reactome | L-Cit [cytosol]

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L-Cit [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-GGA-187586] ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate - Gallus gallus [FailedReaction:R-HSA-9956517] ASS1 variants don't synthesize arginosuccinate - Homo sapiens [Reaction:R-MMU-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Mus musculus [Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Homo sapiens [Reaction:R-CFA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Canis familiaris [Reaction:R-BTA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Bos taurus [Reaction:R-SSC-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Sus scrofa [Reaction:R-XTR-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Xenopus tropicalis [Reaction:R-GGA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Gallus gallus
crossReference	[DatabaseIdentifier:29969] COMPOUND:C00327
dbId	29968
displayName	L-Cit [cytosol]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9760818] D'Eustachio, Peter, 2022-01-03
name	L-Cit L-Citrulline L-Citrulline 2-Amino-5-ureidovaleric acid L-citrulline
producedByEvent	[Reaction:R-GGA-187608] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Gallus gallus [Reaction:R-MMU-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Mus musculus [Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Homo sapiens [Reaction:R-RNO-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Rattus norvegicus [Reaction:R-CFA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Canis familiaris [Reaction:R-BTA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Bos taurus [Reaction:R-SSC-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Sus scrofa [Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Xenopus tropicalis [Reaction:R-GGA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Gallus gallus [Reaction:R-DRE-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Danio rerio [Reaction:R-SPO-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Schizosaccharomyces pombe [Reaction:R-SCE-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Saccharomyces cerevisiae [Reaction:R-DME-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Drosophila melanogaster [Reaction:R-CEL-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Caenorhabditis elegans [Reaction:R-DDI-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Dictyostelium discoideum [Reaction:R-DME-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Drosophila melanogaster [Reaction:R-GGA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Gallus gallus [Reaction:R-XTR-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Xenopus tropicalis [Reaction:R-SSC-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Sus scrofa [Reaction:R-BTA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Bos taurus [Reaction:R-CFA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Canis familiaris [Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Homo sapiens [Reaction:R-MMU-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Mus musculus [Reaction:R-RNO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Rattus norvegicus [Reaction:R-CFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Canis familiaris [Reaction:R-BTA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Bos taurus [Reaction:R-SSC-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Sus scrofa [Reaction:R-DRE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Danio rerio [Reaction:R-GGA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Gallus gallus [Reaction:R-DME-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Drosophila melanogaster [Reaction:R-DDI-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Dictyostelium discoideum [Reaction:R-SPO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Schizosaccharomyces pombe [Reaction:R-SCE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Saccharomyces cerevisiae [Reaction:R-PFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Plasmodium falciparum [Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens [Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens [Reaction:R-MMU-202127] eNOS synthesizes NO - Mus musculus [Reaction:R-MMU-202127] eNOS synthesizes NO - Mus musculus [Reaction:R-RNO-202127] eNOS synthesizes NO - Rattus norvegicus [Reaction:R-RNO-202127] eNOS synthesizes NO - Rattus norvegicus [Reaction:R-BTA-202127] eNOS synthesizes NO - Bos taurus [Reaction:R-BTA-202127] eNOS synthesizes NO - Bos taurus [Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster [Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster [Reaction:R-CEL-202127] eNOS synthesizes NO - Caenorhabditis elegans [Reaction:R-CEL-202127] eNOS synthesizes NO - Caenorhabditis elegans [Reaction:R-DDI-202127] eNOS synthesizes NO - Dictyostelium discoideum [Reaction:R-DDI-202127] eNOS synthesizes NO - Dictyostelium discoideum [Reaction:R-SPO-202127] eNOS synthesizes NO - Schizosaccharomyces pombe [Reaction:R-SPO-202127] eNOS synthesizes NO - Schizosaccharomyces pombe [Reaction:R-SCE-202127] eNOS synthesizes NO - Saccharomyces cerevisiae [Reaction:R-SCE-202127] eNOS synthesizes NO - Saccharomyces cerevisiae [Reaction:R-HSA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Homo sapiens [Reaction:R-MMU-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Mus musculus [Reaction:R-RNO-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Rattus norvegicus
referenceEntity	[ReferenceMolecule:chebi:57743] L-citrulline zwitterion [ChEBI:57743]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29968
updateTrackers	[UpdateTracker:9903763] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v80:[add_removeReferenceEntity] [UpdateTracker:9899560] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v66:[addName] [UpdateTracker:9874115] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v43:[addName]

Referrals

(input)	[Reaction:R-GGA-187586] ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate [FailedReaction:R-HSA-9956517] ASS1 variants don't synthesize arginosuccinate [Reaction:R-MMU-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-CFA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-BTA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-SSC-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-XTR-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA [Reaction:R-GGA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
(output)	[Reaction:R-GGA-187608] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-DME-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-GGA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-XTR-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-SSC-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-BTA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-CFA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-MMU-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-RNO-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-CFA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-BTA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-SSC-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-GGA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-DRE-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-SPO-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-SCE-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-DME-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-CEL-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-DDI-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) [Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-MMU-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-RNO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-CFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-BTA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SSC-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DRE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-GGA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DME-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DDI-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SPO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SCE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-PFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-HSA-202127] eNOS synthesizes NO [Reaction:R-MMU-202127] eNOS synthesizes NO [Reaction:R-RNO-202127] eNOS synthesizes NO [Reaction:R-BTA-202127] eNOS synthesizes NO [Reaction:R-DME-202127] eNOS synthesizes NO [Reaction:R-CEL-202127] eNOS synthesizes NO [Reaction:R-DDI-202127] eNOS synthesizes NO [Reaction:R-SPO-202127] eNOS synthesizes NO [Reaction:R-SCE-202127] eNOS synthesizes NO [Reaction:R-HSA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-MMU-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit [Reaction:R-RNO-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit
(updatedInstance)	[UpdateTracker:9903763] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v80:[add_removeReferenceEntity] [UpdateTracker:9899560] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v66:[addName] [UpdateTracker:9874115] Update Tracker - [SimpleEntity:29968] L-Cit [cytosol] - v43:[addName]

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