Reactome | ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA

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ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA Show undefined attributes

catalystActivity	[CatalystActivity:10652797] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652799
displayName	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
eventOf	[Pathway:R-XTR-70635] Urea cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine - Xenopus tropicalis [Reaction:R-XTR-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol] [SimpleEntity:R-ALL-29968] L-Cit [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-34575] ARSUA [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-XTR-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Xenopus tropicalis [Reaction:R-XTR-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70577
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-XTR-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine
(hasEvent)	[Pathway:R-XTR-70635] Urea cycle
(inferredTo)	[Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA

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