Reactome | DDAH1 hydrolyses ADMA to DMA and L-Cit

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DDAH1 hydrolyses ADMA to DMA and L-Cit Show undefined attributes

catalystActivity	[CatalystActivity:10522229] dimethylargininase activity of DDAH1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10522231
displayName	DDAH1 hydrolyses ADMA to DMA and L-Cit
eventOf	[Pathway:R-SSC-203615] eNOS activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit - Homo sapiens
input	[SimpleEntity:R-ALL-5693375] ADMA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DDAH1 hydrolyses ADMA to DMA and L-Cit H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline
output	[SimpleEntity:R-ALL-5693410] DMA [cytosol] [SimpleEntity:R-ALL-29968] L-Cit [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5693373
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-203615] eNOS activation
(inferredTo)	[Reaction:R-HSA-5693373] DDAH1 hydrolyses ADMA to DMA and L-Cit

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