Reactome | ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)

Schema > Reaction > Entries

ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) Show undefined attributes

catalystActivity	[CatalystActivity:11052394] L-ornithine transmembrane transporter activity of Mitochondrial ornithine transporters [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11052396
displayName	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)
eventOf	[Pathway:R-SPO-70635] Urea cycle - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] - Schizosaccharomyces pombe [Reaction:R-SPO-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Homo sapiens
input	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113567] L-Cit [mitochondrial matrix] [SimpleEntity:R-ALL-29498] L-Orn [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) L-citrulline(in) + L-ornithine(out) + H(+)(in) = L-citrulline(out) + L-ornithine(in) + H(+)(out)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29968] L-Cit [cytosol] [SimpleEntity:R-ALL-113585] L-Orn [mitochondrial matrix]
precedingEvent	[Reaction:R-SPO-70569] arginine + H2O => ornithine + urea [ARG1] - Schizosaccharomyces pombe [Reaction:R-SPO-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-70634
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-70635] Urea cycle
(precedingEvent)	[Reaction:R-SPO-70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] [Reaction:R-SPO-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate
(inferredTo)	[Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)

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