Reactome | respiratory syncytial virus infectious disease

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respiratory syncytial virus infectious disease Show undefined attributes

created	[InstanceEdit:9833928] Orlic-Milacic, Marija, 2023-05-04
databaseName	DOID
dbId	9833927
displayName	respiratory syncytial virus infectious disease
identifier	1273
modified	[InstanceEdit:9835588] Matthews, Lisa, 2023-05-17
name	respiratory syncytial virus infectious disease
referenceDatabase	[ReferenceDatabase:1247631] DOID
schemaClass	Disease
url	https://www.ebi.ac.uk/ols4/ontologies/doid/terms?obo_id=DOID:1273

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(disease)

[Pathway:R-HSA-9820952] Respiratory Syncytial Virus Infection Pathway
[Pathway:R-HSA-9820965] Respiratory syncytial virus (RSV) genome replication, transcription and translation
[Pathway:R-HSA-9820960] Respiratory syncytial virus (RSV) attachment and entry
[BlackBoxEvent:R-HSA-9837625] hRSV A enters host cell through macropinocytosis
[BlackBoxEvent:R-HSA-9837707] Release of hRSV A nucleocapsid from macropinosome
[Complex:R-RSY-9837722] p-SH pentamer [macropinosome membrane]
[Complex:R-HSA-9837711] F trimer:NCL [macropinosome membrane]
[Complex:R-RSY-9837713] F trimer [macropinosome membrane]
[Complex:R-HSA-9837715] Mature G:CX3CR1 [macropinosome membrane]
[EntityWithAccessionedSequence:R-RSY-9837720] Mature G [macropinosome membrane]
[Complex:R-HSA-9837677] hRSV A virion:CX3CR1:NCL [macropinosome membrane]
[Complex:R-HSA-9837670] hRSV A virion:CX3CR1 [macropinosome membrane]
[Complex:R-RSY-9837686] hRSV A virion [macropinosome membrane]
[Reaction:R-HSA-9836467] F protein binds NCL on host cell surface
[BlackBoxEvent:R-HSA-9837543] hRSV A enters host cell through membrane fusion
[Complex:R-HSA-9837549] Mature G:CX3CR1 [plasma membrane]
[Complex:R-HSA-9837548] F trimer:NCL [plasma membrane]
[Complex:R-HSA-9836905] hRSV A virion:CX3CR1:NCL [plasma membrane]
[Reaction:R-HSA-9845143] F inhibitors bind F on RSV virion
[Complex:R-RSY-9845117] F inhibitors:RSV virion [extracellular region]
[DefinedSet:R-ALL-9845120] RSV F inhibitors [extracellular region]
[ChemicalDrug:R-ALL-9845118] rilematovir [extracellular region]
[ProteinDrug:R-ALL-9845136] palivizumab [extracellular region]
[ChemicalDrug:R-ALL-9845090] ziresovir [extracellular region]
[ChemicalDrug:R-ALL-9845154] sisunatovir [extracellular region]
[ProteinDrug:R-ALL-9845111] nirsevimab [extracellular region]
[ProteinDrug:R-ALL-9845110] gontivimab [extracellular region]
[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription
[Reaction:R-HSA-9845192] Asvasiran binds N mRNA
[Complex:R-RSY-9845187] asvasiran:N mRNA [cytosol]
[RNADrug:R-ALL-9845174] asvasiran [cytosol]
[Reaction:R-HSA-9833933] RdRP binds hRSV nucleocapsid
[BlackBoxEvent:R-HSA-9828639] Transcription of respiratory syncytial virus subgenomic positive sense mRNAs
[BlackBoxEvent:R-HSA-9830848] L protein acts as a cap N7 methyltransferase to modify RSV mRNAs
[Complex:R-RSY-9834004] hRSV A nascent mRNAs:RdRP:p-M2-1 [cytosol]
[BlackBoxEvent:R-HSA-9834003] L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs
[Complex:R-RSY-9834005] RSV m7GpppG-mRNAs:RdRP:p-M2-1 [cytosol]
[Reaction:R-HSA-9845222] Lumicitabine binds RdRP on nucleocapsid
[Complex:R-RSY-9845201] lumicitabine:RdRP:p-M2-1:nucleocapsid [cytosol]
[ChemicalDrug:R-ALL-9845196] lumicitabine [cytosol]
[Pathway:R-HSA-9834752] Respiratory syncytial virus genome replication
[BlackBoxEvent:R-HSA-9837392] Packaging of antigenomic RNA of human respiratory syncytial virus
[BlackBoxEvent:R-HSA-9837511] Abortive replication of hRSV A
[DefinedSet:R-RSY-9837507] hRSV A cbVGs [cytosol]
[EntityWithAccessionedSequence:R-RSY-9837388] hRSV copy-back structured dsRNA [cytosol]
[Pathway:R-HSA-9828721] Translation of respiratory syncytial virus mRNAs
[BlackBoxEvent:R-HSA-9828714] M2 mRNA is translated into protein M2-2
[BlackBoxEvent:R-HSA-9828720] SH mRNA is translated into protein SHt
[EntityWithAccessionedSequence:R-RSY-9828710] SHt [endoplasmic reticulum membrane]
[Pathway:R-HSA-9828806] Maturation of hRSV A proteins
[Pathway:R-HSA-9820962] Assembly and release of respiratory syncytial virus (RSV) virions
[BlackBoxEvent:R-HSA-9825340] N protein coats hRSV genomic (-)ssRNA
[BlackBoxEvent:R-HSA-9835151] Packaging of RdRP complex with replicated hRSV A nucleocapsid
[BlackBoxEvent:R-HSA-9835165] Formation of hRSV A matrix lattice
[BlackBoxEvent:R-HSA-9835171] Budding of hRSV A virions from infected cell
[Complex:R-RSY-9835170] Replicated hRSV A virion [extracellular region]
[Complex:R-RSY-9835163] Matrix lattice-enclosed replicated hRSV A nucleocapsid [cytosol]
[Complex:R-RSY-9835160] Replicated hRSV A nucleocapsid:Packaged RdRP:p-M2-1 [cytosol]
[Complex:R-RSY-9835208] Protein N hendecamer [viral capsid]
[EntityWithAccessionedSequence:R-RSY-9835210] Replicated hRSV A genomic (-)ssRNA [viral capsid]
[Complex:R-RSY-9835207] Protein N decamer [viral capsid]
[Reaction:R-HSA-9832168] NS2 (1B) forms a homodimer
[Complex:R-RSY-9832161] NS2 dimer [cytosol]
[BlackBoxEvent:R-HSA-9832040] M2-1 localizes to nucleus
[Complex:R-RSY-9832035] p-M2-1 tetramer [nucleoplasm]
[BlackBoxEvent:R-HSA-9829164] F subunits form trimers at plasma membrane rafts
[Complex:R-RSY-9829197] F trimer [plasma membrane]
[Reaction:R-HSA-9823354] Protein N forms hendecamers
[Reaction:R-HSA-9831712] M dimer is phosphorylated
[BlackBoxEvent:R-HSA-9831677] M dimer gets exported from nucleus
[Complex:R-RSY-9831699] p-M dimer [cytosol]
[Complex:R-RSY-9831701] p-M dimer [nucleoplasm]
[Reaction:R-HSA-9831485] Nascent L binds Mg2+
[BlackBoxEvent:R-HSA-9829183] F1 binds to F2 forming the F subunit
[Complex:R-RSY-9836303] F1:F2 [trans-Golgi network membrane]
[BlackBoxEvent:R-HSA-9831136] SH pentamer is phosphorylated
[BlackBoxEvent:R-HSA-9831152] SH pentamer localizes to host cell plasma membrane
[Complex:R-RSY-9831119] p-SH pentamer [plasma membrane]
[BlackBoxEvent:R-HSA-9832009] M2-1 tetramer gets phosphorylated
[BlackBoxEvent:R-HSA-9832037] P binds to PPP1C complex
[Reaction:R-HSA-9831948] P:PP1 dephosphorylates M2-1
[Complex:R-HSA-9831943] P:PP1 [cytosol]
[Reaction:R-HSA-9830270] Protein M2-1 forms tetramers
[Reaction:R-HSA-9830284] Protein M2-1 tetramers bind protein P tetramer
[BlackBoxEvent:R-HSA-9832782] p-S232-S237-P is further phosphorylated
[Reaction:R-HSA-9832574] NS1 (1C) binds to NS2 (1B)
[BlackBoxEvent:R-HSA-9832577] NS1:NS2 (1C:1B) localizes to mitochondria
[Complex:R-RSY-9832560] NS1:NS2 [mitochondrial matrix]
[Complex:R-RSY-9832578] NS1:NS2 [cytosol]
[BlackBoxEvent:R-HSA-9828723] M2 mRNA is translated into protein M2-1
[Reaction:R-HSA-9832006] Nascent M2-1 binds Zn2+
[Complex:R-RSY-9832032] M2-1:Zn2+ [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828687] Nascent M2-1 [cytosol]
[Reaction:R-HSA-9831514] CK2 phosphorylates nascent P
[EntityWithAccessionedSequence:R-RSY-9832783] p-S232,S237-P [cytosol]
[BlackBoxEvent:R-HSA-9828726] P mRNA is translated into protein P
[EntityWithAccessionedSequence:R-RSY-9831695] Nascent P [cytosol]
[Reaction:R-HSA-9825422] P protein oligomerizes
[BlackBoxEvent:R-HSA-9828719] L mRNA is translated into protein L
[Reaction:R-HSA-9830236] Protein P tetramer binds protein L
[BlackBoxEvent:R-HSA-9830864] Mature G localizes to host cell plasma membrane
[EntityWithAccessionedSequence:R-RSY-9830861] Mature G [plasma membrane]
[BlackBoxEvent:R-HSA-9828716] G mRNA is translated into membrane-bound G protein
[BlackBoxEvent:R-HSA-9830882] Nascent G signal peptide is cleaved at ER membrane
[EntityWithAccessionedSequence:R-RSY-9828696] Nascent G [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9830872] G is N-glycosylated
[Reaction:R-HSA-9830875] G is palmitoylated
[EntityWithAccessionedSequence:R-RSY-9830879] N-glycan G [endoplasmic reticulum-Golgi intermediate compartment membrane]
[BlackBoxEvent:R-HSA-9830867] G is O-glycosylated
[EntityWithAccessionedSequence:R-RSY-9830876] Mature G [trans-Golgi network membrane]
[EntityWithAccessionedSequence:R-RSY-9830866] N-glycan-PALM-G [trans-Golgi network membrane]
[BlackBoxEvent:R-HSA-9828715] F mRNA is translated into nascent protein F
[BlackBoxEvent:R-HSA-9829030] Nascent F signal peptide is cleaved at ER membrane
[EntityWithAccessionedSequence:R-RSY-9829029] F signal peptide [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828695] Nascent F [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9829060] F0 gets N-glycosylated
[EntityWithAccessionedSequence:R-RSY-9829032] F0 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9829047] F0 is palmitoylated
[EntityWithAccessionedSequence:R-RSY-9829051] N-glycan-F0 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9829200] F0 is cleaved, releasing F1, F2, F(110-136)
[EntityWithAccessionedSequence:R-RSY-9829162] F2 [trans-Golgi network membrane]
[EntityWithAccessionedSequence:R-RSY-9829179] F(110-136) [cytosol]
[EntityWithAccessionedSequence:R-RSY-9829176] F1 [trans-Golgi network membrane]
[EntityWithAccessionedSequence:R-RSY-9829024] N-glycan-PALM-F0 [trans-Golgi network membrane]
[BlackBoxEvent:R-HSA-9828717] G mRNA is translated into nascent secreted G protein
[BlackBoxEvent:R-HSA-9830805] Nascent sG localizes to ER lumen, gets glycosylated
[EntityWithAccessionedSequence:R-RSY-9830811] sG signal peptide [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828705] Nascent sG [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9830804] N-/O-glycan-sG is secreted
[EntityWithAccessionedSequence:R-RSY-9830813] sG [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9828725] M mRNA is translated into protein M
[Reaction:R-HSA-9831714] M forms a homodimer
[BlackBoxEvent:R-HSA-9831702] M dimer localizes to nucleus
[Complex:R-RSY-9831694] M dimer [nucleoplasm]
[Complex:R-RSY-9831671] M dimer [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828672] Nascent M [cytosol]
[Pathway:R-HSA-9833110] RSV-host interactions
[BlackBoxEvent:R-HSA-9828722] SH mRNA is translated into protein SH
[BlackBoxEvent:R-HSA-9831107] Nascent SH localizes to Golgi membrane
[Reaction:R-HSA-9831126] SH forms a pentamer
[Complex:R-RSY-9831148] SH pentamer [trans-Golgi network membrane]
[EntityWithAccessionedSequence:R-RSY-9831110] SH [trans-Golgi network membrane]
[Reaction:R-HSA-9837835] SH pentamer transports K+
[Complex:R-RSY-9831102] p-SH pentamer [trans-Golgi network membrane]
[BlackBoxEvent:R-HSA-9834719] Synthesis of negative sense genomic RNA of respiratory syncytial virus
[Complex:R-RSY-9834751] RdRP:p-M2-1:antigenomic hRSV A nucleocapsid [cytosol]
[BlackBoxEvent:R-HSA-9834736] Synthesis of antigenomic RNA of human respiratory syncytial virus
[EntityWithAccessionedSequence:R-RSY-9828693] M2-2 [cytosol]
[Complex:R-RSY-9833931] RdRP:p-M2-1:hRSV A nucleocapsid [cytosol]
[EntityWithAccessionedSequence:R-RSY-9825339] hRSV A genomic (-)ssRNA [cytosol]
[Complex:R-RSY-9823350] Protein N hendecamer [cytosol]
[BlackBoxEvent:R-HSA-9837448] Formation of hRSV A dsRNA intermediate form
[Complex:R-RSY-8985053] hRSV A dsRNA intermediate form [cytosol]
[EntityWithAccessionedSequence:R-RSY-9834730] Replicated hRSV A genomic (-)ssRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9834740] hRSV A antigenomic (+)ssRNA [cytosol]
[Reaction:R-HSA-9837231] ISGylation of BECN1
[EntityWithAccessionedSequence:R-RSY-9836738] RSV 5'-ppp dsRNA, copy-back structured [cytosol]
[Reaction:R-HSA-9837376] RSV G binds CD209,CLEC4M
[Reaction:R-HSA-9836899] sG binds to HSPGs
[EntityWithAccessionedSequence:R-RSY-9830809] sG [extracellular region]
[DefinedSet:R-RSY-9836741] RSV ssRNA [endosome lumen]
[EntityWithAccessionedSequence:R-RSY-9836753] hRSV A genomic (-)ssRNA [endosome lumen]
[Reaction:R-HSA-9837063] NS1 (1C) binds H2BC15
[Complex:R-HSA-9837059] HIST1H2BN:NS1 [nucleoplasm]
[Reaction:R-HSA-9836857] NS1 (1C) binds to Mediator complex
[Complex:R-HSA-9836846] Mediator:NS1 [nucleoplasm]
[BlackBoxEvent:R-HSA-9828718] NS2 (1B) mRNA is translated into protein NS2
[Reaction:R-HSA-9836955] NS2 (1B) binds to MAP1B
[Complex:R-HSA-9836952] NS2:MAP1B(2-2206) [cytosol]
[EntityWithAccessionedSequence:R-RSY-9836733] RSV copy-back structured dsRNA [endosome lumen]
[Reaction:R-HSA-9837136] SH binds to BCAP31
[EntityWithAccessionedSequence:R-RSY-9828680] Nascent SH [endoplasmic reticulum membrane]
[Pathway:R-HSA-9833109] Evasion by RSV of host interferon responses
[Reaction:R-HSA-9833436] RSV N binds PKR
[Complex:R-HSA-9833431] EIF2AK2:N [cytosol]
[Reaction:R-HSA-9717469] NS2 (1B) binds DDX58
[EntityWithAccessionedSequence:R-RSY-9717498] NS2 [cytosol]
[GenomeEncodedEntity:R-RSY-9835308] RSV A dsRNA intermediate form [cytosol]
[EntityWithAccessionedSequence:R-RSY-9832167] NS1 [nucleoplasm]
[Complex:R-HSA-9833445] IRF3:NS1 [nucleoplasm]
[Complex:R-HSA-9833449] CREBBP:NS1 [nucleoplasm]
[EntityWithAccessionedSequence:R-RSY-9825432] p-P [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828691] Nascent L [cytosol]
[Complex:R-RSY-9836528] hRSV A nucleocapsid:Packaged RdRP:p-M2-1 [viral capsid]
[Complex:R-RSY-9836525] Matrix lattice-enclosed hRSV A nucleocapsid [viral capsid]
[Complex:R-RSY-9836527] hRSV A virion [extracellular region]
[Complex:R-HSA-9836529] hRSV A virion:CX3CR1 [plasma membrane]
[Reaction:R-HSA-9836468] G protein binds CX3CR1 on host cell surface
[Reaction:R-HSA-9833446] NS1 (1C) binds to CREBBP
[EntityWithAccessionedSequence:R-RSY-9717482] NS1 [cytosol]
[BlackBoxEvent:R-HSA-9832169] NS1 (1C) localizes to nucleus
[EntityWithAccessionedSequence:R-RSY-9828643] m7G(5')pppAm-capped,polyadenylated NS1 mRNA [cytosol]
[BlackBoxEvent:R-HSA-9828724] NS1 (1C) mRNA is translated into protein NS1 (1C)
[Complex:R-RSY-9832001] p-M2-1 tetramer [cytosol]
[Complex:R-RSY-9834001] RSV m7G(5')pppGm-mRNAs:RdRP:p-M2-1 [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828644] m7G(5')pppAm-capped,polyadenylated NS2 mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828647] m7G(5')pppAm-capped,polyadenylated N mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828646] m7G(5')pppAm-capped,polyadenylated M2 mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828641] m7G(5')pppAm-capped,polyadenylated F mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828652] m7G(5')pppAm-capped,polyadenylated SH mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828649] m7G(5')pppAm-capped,polyadenylated G mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828648] m7G(5')pppAm-capped,polyadenylated M mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828651] m7G(5')pppAm-capped,polyadenylated P mRNA [cytosol]
[EntityWithAccessionedSequence:R-RSY-9828650] m7G(5')pppAm-capped,polyadenylated L mRNA [cytosol]
[DefinedSet:R-RSY-9834766] RSV m7G(5')pppAm-capped, polyadenylated mRNAs [cytosol]
[BlackBoxEvent:R-HSA-9833031] Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs
[Complex:R-HSA-9717514] TRIM25:NS1 [cytosol]
[Reaction:R-HSA-9717525] RSV NS1 (1C) binds TRIM25
[Complex:R-HSA-9833117] NS1:Cul5-SCF [cytosol]
[Reaction:R-HSA-9833107] Association of NS1 (1C) with Cul5 and SCF
[Reaction:R-HSA-9833155] Ubiquitination of STAT2
[EntityWithAccessionedSequence:R-RSY-9832563] NS1 [mitochondrial matrix]
[Complex:R-HSA-9833247] NS1:MAVS [mitochondrial outer membrane]
[Reaction:R-HSA-9833248] NS1 (1C) binds to MAVS
[EntityWithAccessionedSequence:R-RSY-9823348] p-N [cytosol]
[Complex:R-RSY-9823349] Protein N decamer [cytosol]
[Complex:R-HSA-9851982] RSV dsRNA:IFIH1 [cytosol]
[Complex:R-HSA-9833400] RSV dsRNA:IFIH1:N [cytosol]
[Reaction:R-HSA-9833393] N interacts with IFIH1
[Reaction:R-HSA-9823352] Protein N forms decamers
[EntityWithAccessionedSequence:R-RSY-9831167] Nascent N [cytosol]
[BlackBoxEvent:R-HSA-9831166] Nascent N is phosphorylated
[BlackBoxEvent:R-HSA-9828727] N mRNA is translated into protein N
[Reaction:R-HSA-9833441] NS1 (1C) binds to IRF3

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