Reactome | Asvasiran binds N mRNA

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Asvasiran binds N mRNA Show undefined attributes

authored	[InstanceEdit:9845157] Stephan, Ralf, 2023-09-27
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9845183] Stephan, Ralf, 2023-09-28
crossReference	[DatabaseIdentifier:12020771] Mondo:0001577
dbId	9845192
disease	[Disease:9833927] respiratory syncytial virus infectious disease
displayName	Asvasiran binds N mRNA
edited	[InstanceEdit:9845183] Stephan, Ralf, 2023-09-28
eventOf	[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription - Homo sapiens
input	[RNADrug:R-ALL-9845174] asvasiran [cytosol] [EntityWithAccessionedSequence:R-RSY-9828647] m7G(5')pppAm-capped,polyadenylated N mRNA [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9845264] Recent Advances in Inhaled Nanoformulations of Vaccines and Therapeutics Targeting Respiratory Viral Infections [LiteratureReference:9845189] ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients [LiteratureReference:9845250] A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus [LiteratureReference:9845263] RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
maxDepth	1
modified	[InstanceEdit:9853081] Matthews, Lisa, 2023-11-13
name	Asvasiran binds N mRNA
output	[Complex:R-RSY-9845187] asvasiran:N mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9833031] Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs - Homo sapiens
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9845192
summation	[Summation:9845252] Asvasiran (ALN-RSV01) is a naked siRNA targeting the RSV nuc...

Referrals

(hasEvent)

[Pathway:R-HSA-9828642] Respiratory syncytial virus genome transcription